Universität zu Köln

Pfister, David, Haidl, Friederike, Paffenholz, Pia, Nestler, Tim and Heidenreich, Axel (2019). Personalised medicine in prostate cancer. Aktuelle Urol., 50 (5). S. 509 - 513. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8820

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Abstract

Prostate cancer is the most common cancer in men. Its incidence increases with age. New treatment options have been introduced and there is a clear trend to more aggressive treatment in newly diagnosed metastatic disease. While prolonged survival of patients has been achieved, the new expensive drugs are associated with an increased burden on the healthcare system. Meanwhile, similarly to other tumour entities, there is a pool of different drugs available with comparable oncologic efficacy, but different side-effects. Effective diagnostic investigation and treatment decisions require additional factors, above and beyond clinical parameters, for a more individual treatment approach. In castration-resistant prostate cancer (CRPCA), there are promising molecular markers for treatment decisions. In metastatic disease, liquid biopsies and next generation sequencing of metastatic biopsies allow for genetic analysis. These will provide more insight into tumour dynamics and allow for patient selection. This review concentrates on molecular markers in CRPCA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfister, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestler, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143200
DOI:	10.1055/a-0972-0824
Journal or Publication Title:	Aktuelle Urol.
Volume:	50
Number:	5
Page Range:	S. 509 - 513
Date:	2019
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-8820
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OLAPARIB MAINTENANCE THERAPY; INCREASED SURVIVAL; FREE DNA; CHEMOTHERAPY; ABIRATERONE; RESISTANCE; BLOOD; AR-V7; ENZALUTAMIDE; ASSOCIATION Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14320