Universität zu Köln

Zimmer, P., Schenk, A. and Elter, T. (2019). Molecular and biological mechanism of physical exercise on carcinogenesis. Gastroenterologe, 14 (5). S. 332 - 340. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-969X

Full text not available from this repository.

Abstract

General physical activity and physical exercise have become a meaningful supportive therapy in oncology, since they have proven to reduce several disease- and treatment-specific side effects and to increase patients' quality of life. Ample evidence from epidemiological investigations suggests that regular physical activity significantly decreases cancer risk and mortality. However, prospective randomized controlled trials are still lacking. Of note, such trials have many trapdoors and are more complex than usual pharmaceutical trials. In order to improve general physical activity and exercise recommendations, more mechanistic research is urgently needed. Against this background, this article will provide an overview on mechanistic studies, investigating the impact of exercise interventions on tumorgenesis and the progress of disease. In addition to alterations in systemic inflammatory signaling, the activation of tumor-competetive lymphocytes as well direct effects on the tumor microenvironment will be discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimmer, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elter, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143266
DOI:	10.1007/s11377-019-0379-5
Journal or Publication Title:	Gastroenterologe
Volume:	14
Number:	5
Page Range:	S. 332 - 340
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-969X
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NATURAL-KILLER-CELLS; BREAST-CANCER; INTENSITY EXERCISE; NK-CELLS; IMPACT; CYTOTOXICITY; MORTALITY; SURVIVORS; PATHWAY; HEALTH Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14326