Universität zu Köln

Gehrlach, Daniel A., Dolensek, Nejc ORCID: 0000-0002-9370-7210, Klein, Alexandra S., Chowdhury, Ritu Roy, Matthys, Arthur ORCID: 0000-0002-4616-7821, Junghaenel, Michaela, Gaitanos, Thomas N., Podgornik, Alja, Black, Thomas D., Vaka, Narasimha Reddy, Conzelmann, Karl-Klaus ORCID: 0000-0002-8614-3656 and Gogolla, Nadine (2019). Aversive state processing in the posterior insular cortex. Nat. Neurosci., 22 (9). S. 1424 - 1443. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1726

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Abstract

Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral adaptation is poorly understood. By combining data from fiber photometry, optogenetics, awake two-photon calcium imaging and comprehensive whole-brain viral tracings, we here uncover a role for the posterior insula in processing aversive sensory stimuli and emotional and bodily states, as well as in exerting prominent top-down modulation of ongoing behaviors in mice. By employing projection-specific optogenetics, we describe an insula-to-central amygdala pathway to mediate anxiety-related behaviors, while an independent nucleus accumbens-projecting pathway regulates feeding upon changes in bodily state. Together, our data support a model in which the posterior insular cortex can shift behavioral strategies upon the detection of aversive internal states, providing a new entry point to understand how alterations in insula circuitry may contribute to neuropsychiatric conditions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gehrlach, Daniel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolensek, Nejc UNSPECIFIED orcid.org/0000-0002-9370-7210 UNSPECIFIED Klein, Alexandra S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chowdhury, Ritu Roy UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthys, Arthur UNSPECIFIED orcid.org/0000-0002-4616-7821 UNSPECIFIED Junghaenel, Michaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaitanos, Thomas N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Podgornik, Alja UNSPECIFIED UNSPECIFIED UNSPECIFIED Black, Thomas D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vaka, Narasimha Reddy UNSPECIFIED UNSPECIFIED UNSPECIFIED Conzelmann, Karl-Klaus UNSPECIFIED orcid.org/0000-0002-8614-3656 UNSPECIFIED Gogolla, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143318
DOI:	10.1038/s41593-019-0469-1
Journal or Publication Title:	Nat. Neurosci.
Volume:	22
Number:	9
Page Range:	S. 1424 - 1443
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1546-1726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; PHYSIOLOGICAL CONDITION; BRAIN; ANXIETY; INTEROCEPTION; RESPONSES; AMYGDALA; CIRCUIT; NEURONS; ORGANIZATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14331