Gehrlach, Daniel A., Dolensek, Nejc ORCID: 0000-0002-9370-7210, Klein, Alexandra S., Chowdhury, Ritu Roy, Matthys, Arthur ORCID: 0000-0002-4616-7821, Junghaenel, Michaela, Gaitanos, Thomas N., Podgornik, Alja, Black, Thomas D., Vaka, Narasimha Reddy, Conzelmann, Karl-Klaus ORCID: 0000-0002-8614-3656 and Gogolla, Nadine (2019). Aversive state processing in the posterior insular cortex. Nat. Neurosci., 22 (9). S. 1424 - 1443. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1726

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Abstract

Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral adaptation is poorly understood. By combining data from fiber photometry, optogenetics, awake two-photon calcium imaging and comprehensive whole-brain viral tracings, we here uncover a role for the posterior insula in processing aversive sensory stimuli and emotional and bodily states, as well as in exerting prominent top-down modulation of ongoing behaviors in mice. By employing projection-specific optogenetics, we describe an insula-to-central amygdala pathway to mediate anxiety-related behaviors, while an independent nucleus accumbens-projecting pathway regulates feeding upon changes in bodily state. Together, our data support a model in which the posterior insular cortex can shift behavioral strategies upon the detection of aversive internal states, providing a new entry point to understand how alterations in insula circuitry may contribute to neuropsychiatric conditions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gehrlach, Daniel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolensek, NejcUNSPECIFIEDorcid.org/0000-0002-9370-7210UNSPECIFIED
Klein, Alexandra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chowdhury, Ritu RoyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthys, ArthurUNSPECIFIEDorcid.org/0000-0002-4616-7821UNSPECIFIED
Junghaenel, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaitanos, Thomas N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Podgornik, AljaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Black, Thomas D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaka, Narasimha ReddyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conzelmann, Karl-KlausUNSPECIFIEDorcid.org/0000-0002-8614-3656UNSPECIFIED
Gogolla, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-143318
DOI: 10.1038/s41593-019-0469-1
Journal or Publication Title: Nat. Neurosci.
Volume: 22
Number: 9
Page Range: S. 1424 - 1443
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: NEW YORK
ISSN: 1546-1726
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FUNCTIONAL CONNECTIVITY; PHYSIOLOGICAL CONDITION; BRAIN; ANXIETY; INTEROCEPTION; RESPONSES; AMYGDALA; CIRCUIT; NEURONS; ORGANIZATIONMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14331

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