Universität zu Köln

Rashid, Khalid, Akhtar-Schaefer, Isha and Langmann, Thomas (2019). Microglia in Retinal Degeneration. Front. Immunol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

The retina is a complex tissue with multiple cell layers that are highly ordered. Its sophisticated structure makes it especially sensitive to external or internal perturbations that exceed the homeostatic range. This necessitates the continuous surveillance of the retina for the detection of noxious stimuli. This task is mainly performed by microglia cells, the resident tissue macrophages which confer neuroprotection against transient pathophysiological insults. However, under sustained pathological stimuli, microglial inflammatory responses become dysregulated, often worsening disease pathology. In this review, we provide an overview of recent studies that depict microglial responses in diverse retinal pathologies that have degeneration and chronic immune reactions as key pathophysiological components. We also discuss innovative immunomodulatory therapy strategies that dampen the detrimental immunological responses to improve disease outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rashid, Khalid UNSPECIFIED UNSPECIFIED UNSPECIFIED Akhtar-Schaefer, Isha UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144060
DOI:	10.3389/fimmu.2019.01975
Journal or Publication Title:	Front. Immunol.
Volume:	10
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-3224
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTIC-NERVE HEAD; DIAZEPAM-BINDING INHIBITOR; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; OPEN-ANGLE GLAUCOMA; RD10 MOUSE MODEL; MACULAR DEGENERATION; TRANSLOCATOR PROTEIN; IN-VIVO; POLYSIALIC ACID Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14406