Universität zu Köln

Fischer, Michael R., Schermann, Anja I., Twelkmeyer, Trix, Lorenz, Beate, Wegner, Joanna, Jonuleit, Helmut and von Stebut, Esther (2019). Humanized mice in cutaneous leishmaniasis-Suitability analysis of human PBMC transfer into immunodeficient mice. Exp. Dermatol., 28 (9). S. 1087 - 1091. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

Humanized mice represent a suitable preclinical test system for example therapeutic interventions in various disease settings, including infections. Here, we intended to establish such system for cutaneous leishmaniasis by infecting T, B and NK cell-deficient mice adoptively transferred with human peripheral blood mononuclear cells (PBMC). L major infection led to the establishment of parasite lesions harbouring viable parasites and human T cells, but parasite elimination was not seen due to a species-specific activity of T cell-derived human IFN gamma. In addition, up to 50% of infected mice succumbed to severe graft-versus-host disease. In summary, even though long-term disease outcome assessments are impossible, this model of humanized mice can be used for studying lesion development and generation of oligoclonal anti-parasite human T cell responses in vivo.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fischer, Michael R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schermann, Anja I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Twelkmeyer, Trix UNSPECIFIED UNSPECIFIED UNSPECIFIED Lorenz, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegner, Joanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonuleit, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-145938
DOI:	10.1111/exd.13999
Journal or Publication Title:	Exp. Dermatol.
Volume:	28
Number:	9
Page Range:	S. 1087 - 1091
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOUSE MODEL; INFECTION Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14593