Menghini-Mueller, Stephanie, Studerus, Erich ORCID: 0000-0003-4233-0182, Ittig, Sarah, Heitz, Ulrike, Egloff, Laura ORCID: 0000-0001-7809-7541, Andreou, Christina ORCID: 0000-0002-6656-9043, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark ORCID: 0000-0002-3525-6415, de Haan, Lieuwe, Nelson, Barnaby ORCID: 0000-0002-6263-2332, Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, Nordentoft, Merete ORCID: 0000-0003-4895-7023, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Sachs, Gabriele, Rutten, Bart P., van Os, Jim ORCID: 0000-0002-7245-1586, Riecher-Rossler, Anita, McGuire, Philip, Calem, Maria, Tognin, Stefania ORCID: 0000-0002-1983-9135, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Pantelis, Christos ORCID: 0000-0002-9565-0238, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan ORCID: 0000-0002-5792-3987, Rapp, Charlotte, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa ORCID: 0000-0003-2697-1342, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Racioppi, Anna, Cristobal-Narvaez, Paula, Kwapil, Thomas R., Monsonet, Manel, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Glenthoj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette and Delespau, Philippe A. (2019). Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning - Results from the EU-GEI study. Eur. Psychiat., 59. S. 52 - 60. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1778-3585

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Abstract

Background: Gender differences in symptomatology in chronic schizophrenia and first episode psychosis patients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning in patients with an at-risk mental state (ARMS) for psychosis. Methods: The sample consisted of 336 ARMS patients (159 women) from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Clinical symptoms, drug use, comorbidity and functioning were assessed at first presentation to an early detection center using structured interviews. Results: In unadjusted analyses, men were found to have significantly higher rates of negative symptoms and current cannabis use while women showed higher rates of general psychopathology and more often displayed comorbid affective and anxiety disorders. No gender differences were found for global functioning. The results generally did not change when corrected for possible cofounders (e.g. cannabis use). However, most differences did not withstand correction for multiple testing. Conclusions: Findings indicate that gender differences in symptomatology and comorbidity in ARMS are similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and would only be reliably detected in studies with high statistical power. Moreover, such small effects would likely not be clinically meaningful. (C) 2019 Published by Elsevier Masson SAS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Menghini-Mueller, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Studerus, ErichUNSPECIFIEDorcid.org/0000-0003-4233-0182UNSPECIFIED
Ittig, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heitz, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Egloff, LauraUNSPECIFIEDorcid.org/0000-0001-7809-7541UNSPECIFIED
Andreou, ChristinaUNSPECIFIEDorcid.org/0000-0002-6656-9043UNSPECIFIED
Valmaggia, Lucia R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kempton, Matthew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Gaag, MarkUNSPECIFIEDorcid.org/0000-0002-3525-6415UNSPECIFIED
de Haan, LieuweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, BarnabyUNSPECIFIEDorcid.org/0000-0002-6263-2332UNSPECIFIED
Barrantes-Vidal, NeusUNSPECIFIEDorcid.org/0000-0002-8671-1238UNSPECIFIED
Nordentoft, MereteUNSPECIFIEDorcid.org/0000-0003-4895-7023UNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-6022-2364UNSPECIFIED
Sachs, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutten, Bart P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Os, JimUNSPECIFIEDorcid.org/0000-0002-7245-1586UNSPECIFIED
Riecher-Rossler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuire, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calem, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tognin, StefaniaUNSPECIFIEDorcid.org/0000-0002-1983-9135UNSPECIFIED
Modinos, GemmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Velthorst, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraan, Tamar C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Dam, Daniella S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burger, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGorry, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amminger, G. PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDorcid.org/0000-0002-9565-0238UNSPECIFIED
Politis, AthenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goodall, JoanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDorcid.org/0000-0002-5792-3987UNSPECIFIED
Rapp, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smieskova, RenataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressan, RodrigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gadelha, AryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brietzke, ElisaUNSPECIFIEDorcid.org/0000-0003-2697-1342UNSPECIFIED
Asevedo, GraccielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Asevedo, ElsonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zugman, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominguez-Martinez, TecelliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racioppi, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cristobal-Narvaez, PaulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kwapil, Thomas R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monsonet, ManelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kazes, MathildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daban, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bourgin, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gay, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mam-Lam-Fook, CeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krebs, Marie-OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordholm, DorteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Randers, LasseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krakauer, KristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, BirteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gebhard, DominikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnhold, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkotter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasser, IrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winklbaur, BernadetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delespau, Philippe A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-147037
DOI: 10.1016/j.eurpsy.2019.04.007
Journal or Publication Title: Eur. Psychiat.
Volume: 59
Page Range: S. 52 - 60
Date: 2019
Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication: ISSY-LES-MOULINEAUX
ISSN: 1778-3585
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ULTRA-HIGH RISK; COMPREHENSIVE ASSESSMENT; MENTAL-DISORDERS; RATING-SCALE; DEPRESSION; RELIABILITY; VALIDITY; ANXIETY; ONSET; STATEMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14703

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