Universität zu Köln

Thangarajah, Fabinshy, Morgenstern, Bernd, Pahmeyer, Caroline, Schiffmann, Lars Mortimer, Puppe, Julian, Mallmann, Peter, Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Buettner, Reinhard, Alidousty, Christina, Holz, Barbara, Scheel, Andreas H. and Schultheis, Anne Maria (2019). Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva. J. Cancer Res. Clin. Oncol., 145 (6). S. 1651 - 1661. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

PurposeSquamous cell carcinoma of the vulva (SQCV) is the fifth most common cancer in women and accounts for about 5% of all genital cancers in women. The PD-L1 signaling pathway is activated in many malignant neoplasms and its blockade enhances anti-cancer immunity. The aim of our study was to examine the protein expression of PD-L1 and PD-1 in squamous cell cancer of the vulva, its correlations with clinicopathologic features and prognostic value.MethodsPatients with SQCV treated in one institution were used for the analyses. PD-L1 immunohistochemistry was performed on 4 mu m-thick section of the respective FFPE tissue blocks using the 28-8 antibody. PD-L1 scoring was performed separately for tumour cells (TC) and tumour associated immune cells. DNA was extracted to determine HPV status. Kaplan-Meier estimates for disease-free-survival and overall-survival were calculated and compared by log-rank test.ResultsPD-L1 expression in tumour cells could be observed in 32.9% of the patients. The expression of PD-L1 in peritumoural immune cells was confirmed in 91.4% of the patients. A significant correlation between PD-L1 expression in tumour cells and tumour stage was detected (p=0.007). PD-L1 expression was independent from HPV status. Using the log-rank test we could not prove any significant differences in disease-free survival (p=0.434) and overall survival (p=0.858). Regression analysis showed that nodal status is a predictive factor of survival (p<0.001).ConclusionThe present study showed that a relevant amount of patients with squamous cell cancer of the vulva express PD-L1 in both, tumour cells and tumour-associated immune cells. Furthermore, the significant correlation of PD-L1 expression in TCs with tumour stage indicated the clinical impact of PD-L1 expression during tumour development. These data indicate that SQCV might be amenable to immune checkpoint-inhibition and constitute a rational for the future clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thangarajah, Fabinshy UNSPECIFIED UNSPECIFIED UNSPECIFIED Morgenstern, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Pahmeyer, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffmann, Lars Mortimer UNSPECIFIED UNSPECIFIED UNSPECIFIED Puppe, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Alidousty, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Holz, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheel, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultheis, Anne Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-147250
DOI:	10.1007/s00432-019-02915-1
Journal or Publication Title:	J. Cancer Res. Clin. Oncol.
Volume:	145
Number:	6
Page Range:	S. 1651 - 1661
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1335
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRAEPITHELIAL NEOPLASIA; CARCINOMA; NIVOLUMAB; BLOCKADE; SAFETY; IMMUNOTHERAPY; BIOMARKERS; ANTIBODY; B7-H1; ASSAY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14725