Rayner, Christopher ORCID: 0000-0003-2950-343X, Coleman, Jonathan R. I., Purves, Kirstin L. ORCID: 0000-0002-8110-5554, Hodsoll, John ORCID: 0000-0001-7546-9901, Goldsmith, Kimberley ORCID: 0000-0002-0620-7868, Alpers, Georg W., Andersson, Evelyn, Arolt, Volker, Boberg, Julia, Bogels, Susan, Creswell, Cathy ORCID: 0000-0003-1889-0956, Cooper, Peter, Curtis, Charles ORCID: 0000-0002-2992-1941, Deckert, Juergen, Domschke, Katharina, El Alaoui, Samir, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Grocholewski, Anja ORCID: 0000-0002-9938-9188, Hahlweg, Kurt, Hamm, Alfons, Hedman, Erik, Heiervang, Einar R., Hudson, Jennifer L., Joehren, Peter, Keers, Robert, Kircher, Tilo ORCID: 0000-0002-2514-2625, Lang, Thomas, Lavebratt, Catharina, Lee, Sang-hyuck, Lester, Kathryn J., Lindefors, Nils, Margraf, Jurgen, Nauta, Maaike, Pane-Farre, Christiane A., Pauli, Paul, Rapee, Ronald M., Reif, Andreas, Rief, Winfried, Roberts, Susanna, Schalling, Martin, Schneider, Silvia, Silverman, Wendy K., Stroehle, Andreas, Teismann, Tobias, Thastum, Mikael ORCID: 0000-0001-8582-5682, Wannemueller, Andre, Weber, Heike ORCID: 0000-0002-9421-1292, Wittchen, Hans-Ulrich, Wolf, Christiane, Ruck, Christian, Breen, Gerome ORCID: 0000-0003-2053-1792 and Eley, Thalia C. (2019). A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders. Transl. Psychiatr., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2158-3188

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Abstract

Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (r(g) approximate to 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Currently, there are no strong predictors of outcome. Therapygenetics research aims to identify genetic predictors of prognosis following therapy. We performed genome-wide association meta-analyses of symptoms following cognitive behavioural therapy in adults with anxiety disorders (n = 972), adults with major depressive disorder (n = 832) and children with anxiety disorders (n = 920; meta-analysis n = 2724). We (h(SNP)(2)) and polygenic scoring was used to examine genetic associations between therapy outcomes and psychopathology, personality and estimated the variance in therapy outcomes that could be explained by common genetic variants learning. No single nucleotide polymorphisms were strongly associated with treatment outcomes. No significant estimate of h(SNP)(2) could be obtained, suggesting the heritability of therapy outcome is smaller than our analysis was powered to detect. Polygenic scoring failed to detect genetic overlap between therapy outcome and psychopathology, personality or learning. This study is the largest therapygenetics study to date. Results are consistent with previous, similarly powered genome-wide association studies of complex traits.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rayner, ChristopherUNSPECIFIEDorcid.org/0000-0003-2950-343XUNSPECIFIED
Coleman, Jonathan R. I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Purves, Kirstin L.UNSPECIFIEDorcid.org/0000-0002-8110-5554UNSPECIFIED
Hodsoll, JohnUNSPECIFIEDorcid.org/0000-0001-7546-9901UNSPECIFIED
Goldsmith, KimberleyUNSPECIFIEDorcid.org/0000-0002-0620-7868UNSPECIFIED
Alpers, Georg W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andersson, EvelynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arolt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boberg, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogels, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Creswell, CathyUNSPECIFIEDorcid.org/0000-0003-1889-0956UNSPECIFIED
Cooper, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curtis, CharlesUNSPECIFIEDorcid.org/0000-0002-2992-1941UNSPECIFIED
Deckert, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domschke, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El Alaoui, SamirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, LydiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fydrich, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, Alexander L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grocholewski, AnjaUNSPECIFIEDorcid.org/0000-0002-9938-9188UNSPECIFIED
Hahlweg, KurtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamm, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hedman, ErikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiervang, Einar R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hudson, Jennifer L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joehren, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keers, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kircher, TiloUNSPECIFIEDorcid.org/0000-0002-2514-2625UNSPECIFIED
Lang, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lavebratt, CatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Sang-hyuckUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lester, Kathryn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindefors, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margraf, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nauta, MaaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pane-Farre, Christiane A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauli, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rapee, Ronald M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reif, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rief, WinfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roberts, SusannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schalling, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverman, Wendy K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stroehle, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teismann, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thastum, MikaelUNSPECIFIEDorcid.org/0000-0001-8582-5682UNSPECIFIED
Wannemueller, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, HeikeUNSPECIFIEDorcid.org/0000-0002-9421-1292UNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruck, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breen, GeromeUNSPECIFIEDorcid.org/0000-0003-2053-1792UNSPECIFIED
Eley, Thalia C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-147893
DOI: 10.1038/s41398-019-0481-y
Journal or Publication Title: Transl. Psychiatr.
Volume: 9
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2158-3188
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RANDOMIZED CONTROLLED-TRIAL; PANIC DISORDER; MAJOR DEPRESSION; PSYCHOLOGICAL TREATMENT; GENETIC EPIDEMIOLOGY; SOMATIC DISORDERS; MENTAL-DISORDERS; DSM-IV; REPLICATION; PREDICTORSMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14789

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