Universität zu Köln

Thanarajah, Sharmili Edwin, Hoffstall, Vera, Rigoux, Lionel, Hanssen, Ruth, Bruening, Jens C. and Tittgemeyer, Marc ORCID: 0000-0001-5072-2149 (2019). The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Sci Rep, 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Olfactory perception determines food selection behavior depending on energy homeostasis and nutritional status. The mechanisms, however, by which metabolic signals in turn regulate olfactory perception remain largely unclear. Given the evidence for direct insulin action on olfactory neurons, we tested olfactory performance (olfactory threshold, olfactory discrimination) in 36 subjects of normal- and overweight after administration of three different insulin doses (40 I.U., 100 I.U., 160 I.U.) or corresponding placebo volume in a within-subject design. Poor peripheral insulin sensitivity as quantified by HOMA-IR in baseline condition and increases in systemic insulin levels reactive to intranasal administration predicted poor olfactory performance. In contrast, intranasal insulin enhanced odor perception with a dose-dependent improvement of olfactory threshold. These findings indicate a new diametric impact of insulin on olfactory perception depending on peripheral or central availability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thanarajah, Sharmili Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstall, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Rigoux, Lionel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanssen, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED orcid.org/0000-0001-5072-2149 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-148353
DOI:	10.1038/s41598-019-43693-7
Journal or Publication Title:	Sci Rep
Volume:	9
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ODOR IDENTIFICATION; DISCRIMINATION; PERFORMANCE; HUNGER; HOMEOSTASIS; RESISTANCE; NEURONS; GLUCOSE; PLASMA; SYSTEM Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14835