Surowy, H. M., Giesen, A. K., Otte, J., Buettner, R., Falkenstein, D., Friedl, H., Meier, F., Petzsch, P., Wachtmeister, T., Westphal, D., Wieczorek, D., Wruck, W., Adjaye, J., Ruetten, A. and Redler, S. (2019). Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma. Br. J. Dermatol., 180 (5). S. 1150 - 1161. HOBOKEN: WILEY. ISSN 1365-2133

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Abstract

Background Sweat gland carcinomas are rare cutaneous adnexal malignancies. Aggressive digital papillary adenocarcinoma (ADPA) represents a very rare subentity, thought to arise almost exclusively from the sweat glands of the fingers and toes. The aetiology of sweat gland carcinomas and ADPA is largely unknown. ADPAs are most likely driven by somatic mutations. However, somatic mutation patterns are largely unexplored, creating barriers to the development of effective therapeutic approaches to the treatment of ADPA. Objectives To investigate the transcriptome profile of ADPA using a sample of eight formalin-fixed, paraffin-embedded tissue samples of ADPA and healthy control tissue. Methods Transcriptome profiling was performed using the Affymetrix PrimeView Human Gene Expression Microarray and findings were validated via reverse transcription of RNA and real-time quantitative polymerase chain reaction. Results Transcriptome analyses showed increased tumour expression of 2266 genes, with significant involvement of cell cycle, ribosomal and crucial cancer pathways. Our results point to tumour overexpression of FGFR2 (P = 0 center dot 001). Conclusions The results indicate the involvement of crucial oncogenic driver pathways, highlighting cell cycle and ribosomal pathways in the aetiology of ADPA. Suggested tumour overexpression of FGFR2 raises the hope that targeting the fibroblast growth factor (FGF)/FGF receptor axis might be a promising treatment for ADPA and probably for the overall group of sweat gland carcinomas.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Surowy, H. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giesen, A. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otte, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkenstein, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedl, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meier, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petzsch, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachtmeister, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westphal, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieczorek, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wruck, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adjaye, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruetten, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Redler, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-149825
DOI: 10.1111/bjd.17446
Journal or Publication Title: Br. J. Dermatol.
Volume: 180
Number: 5
Page Range: S. 1150 - 1161
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1365-2133
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GASTRIC-CANCER; OF-FUNCTION; GROWTH; CELLS; OVEREXPRESSION; ONCOLOGY; THERAPY; FGFR2; PROGNOSIS; ADENOMAMultiple languages
DermatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14982

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