Universität zu Köln

Schumacher, Sarah, Niemeyer, Helen, Engel, Sinha ORCID: 0000-0001-9289-7094, Cwik, Jan Christopher ORCID: 0000-0002-2290-353X, Laufer, Sebastian, Klusmann, Hannah and Knaevelsrud, Christine (2019). HPA axis regulation in posttraumatic stress disorder: A meta-analysis focusing on potential moderators. Neurosci. Biobehav. Rev., 100. S. 35 - 58. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7528

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Abstract

Posttraumatic stress disorder (PTSD) is often associated with alterations in the hypothalamic-pituitary-adrenal (HPA) axis. Previous findings are inconsistent, possibly due to trauma exposure of controls or different hormone measurement methods. We investigated cortisol, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) in adults with clinical PTSD under basal or challenged conditions (Prospero registration no. CRD42016041690). A search of PubMed, Scopus, Medlin, PsycINFO, Pilots/ProQuest, and Web of Science resulted in 108 included studies (N = 6484). Morning and 24 h cortisol were significantly lower in PTSD than in controls (g = - 0.21; 95% CI: -0.42-( - 0.01); g= -0.31; CI: - 0.60-( - 0.03)). Significant cortisol increases occurred after awakening in PTSD (g = 0.40; CI: 0.13-0.67) and in non-exposed controls (g = 0.96; CI: 0.59-1.33). Evening DHEA was significantly higher in PTSD than in non-exposed controls (g = 0.58; CI: 0.17-0.99). All groups showed large cortisol suppression effects after dexamethasone administration. Overall, the potential moderators investigated did not reveal a consistent pattern of HPA alterations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schumacher, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Niemeyer, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Sinha UNSPECIFIED orcid.org/0000-0001-9289-7094 UNSPECIFIED Cwik, Jan Christopher UNSPECIFIED orcid.org/0000-0002-2290-353X UNSPECIFIED Laufer, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Klusmann, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Knaevelsrud, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150075
DOI:	10.1016/j.neubiorev.2019.02.005
Journal or Publication Title:	Neurosci. Biobehav. Rev.
Volume:	100
Page Range:	S. 35 - 58
Date:	2019
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-7528
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SALIVARY CORTISOL; PUBLICATION BIAS; FUNNEL-PLOT; DHEA-S; RESPONSES; SYMPTOMS; FILL; TRIM Multiple languages Behavioral Sciences; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15007