Universität zu Köln

Prinz, Nicole, Zolin, Anna, Konrad, Katja, Naehrlich, Lutz ORCID: 0000-0002-7146-6997, Laubner, Katharina, Olesen, Hanne V., Bauer, Maria, Jung, Andreas, Frischer, Thomas and Holl, Reinhard W. (2019). Characteristics of cystic fibrosis-related diabetes: Data from two different sources the European cystic fibrosis society patient registry and German/Austrian diabetes prospective follow-up registry. Pediatr. Diabetes, 20 (3). S. 255 - 263. HOBOKEN: WILEY. ISSN 1399-5448

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Abstract

Background Standardized patient registries provide a unique basis to get insight into cystic fibrosis (CF)-related diabetes (CFRD), the most common comorbidity in CF. Methods A total of 3853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (diabetes patienten verlaufsdokumentation [DPV]) were studied. To adjust for age and sex, multivariable regression was used (SAS 9.4). Results DPV subjects were younger (26.5 [20.2-32.6] vs 28.3 [21.7-36.0] years, P < 0.001) and more often female (59.6 vs 50.9%, P < 0.001). In both registries, F508del homozygotes were most frequent, with higher proportion in DPV (80.9 vs 57.8%, P = 0.003). After adjustment, lung-transplantation (LTX) was more common in ECFSPR (18.9 vs 4.9%, P < 0.001), although duration since LTX (4.8 +/- 0.2 vs 5.5 +/- 0.7 years, P = 0.33) did not differ. In DPV patients without LTX, a lower BMI (19.6 +/- 0.1 vs 21.0 +/- 0.1 kg/m(2), P < 0.001), higher proportion of underweight (41.2 vs 20.2%, P < 0.001) and a tendency towards worse lung function (%FEV1: 42.3 +/- 4.2 vs 48.3 +/- 0.5%, P = 0.16) were observed. Conclusions Between both registries, demographic and clinical differences of CFRD were present. Besides different kind of data sources, diverse treatment structures between countries may play a role. The results may further indicate a more serious illness in patients treated in specialized diabetes clinics, documenting their data in DPV.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prinz, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Zolin, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Naehrlich, Lutz UNSPECIFIED orcid.org/0000-0002-7146-6997 UNSPECIFIED Laubner, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Olesen, Hanne V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Frischer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150157
DOI:	10.1111/pedi.12831
Journal or Publication Title:	Pediatr. Diabetes
Volume:	20
Number:	3
Page Range:	S. 255 - 263
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-5448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL CARE GUIDELINES; NUTRITIONAL-STATUS; LUNG-FUNCTION; YOUNG-ADULTS; INSULIN; TYPE-1; MULTICENTER; ADOLESCENTS; CHILDREN; TRENDS Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15015