Universität zu Köln

Yang, Yongjie, van der Klaauw, Agatha A., Zhu, Liangru, Cacciottolo, Tessa M., He, Yanlin ORCID: 0000-0002-5471-9016, Stadler, Lukas K. J., Wang, Chunmei, Xu, Pingwen, Saito, Kenji, Hinton, Antentor, Yan, Xiaofeng, Keogh, Julia M., Henning, Elana, Banton, Matthew C., Hendricks, Audrey E., Bochukova, Elena G., Mistry, Vanisha, Lawler, Katherine L., Liao, Lan, Xu, Jianming, O'Rahilly, Stephen, Tong, Qingchun ORCID: 0000-0002-4561-2540, Barroso, Ines, O'Malley, Bert W., Farooqi, I. Sadaf, Xu, Yong, Balasubramanian, Senduran, Clapham, Peter, Coates, Guy, Cox, Tony, Daly, Allan, Danecek, Petr, Du, Yuanping, Durbin, Richard, Edkins, Sarah, Ellis, Peter, Flicek, Paul, Guo, Xiaosen, Guo, Xueqin, Huang, Liren, Jackson, David K., Joyce, Chris, Keane, Thomas, Kolb-Kokocinski, Anja, Langford, Cordelia, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Maslen, John, McCarthy, Shane, Muddyman, Dawn, Quail, Michael A., Stalker, Jim, Sun, Jianping, Tian, Jing, Wang, Guangbiao, Wang, Jun, Wang, Yu, Wong, Kim, Zhang, Pingbo, Birney, Ewan, Boustred, Chris, Brion, Marie-Jo, Chen, Lu, Clement, Gail, Danecek, Petr, Smith, George Davey ORCID: 0000-0002-1407-8314, Day, Ian N. M., Day-Williams, Aaron, Down, Thomas, Dunham, Ian, Durbin, Richard, Evans, David M., Fatemifar, Ghazaleh, Gaunt, Tom R., Geihs, Matthias, Greenwood, Celia M. T., Hart, Deborah, Howie, Bryan, Huang, Jie, Hubbard, Tim, Hysi, Pirro, Iotchkova, Valentina, Jamshidi, Yalda ORCID: 0000-0003-0151-6482, Kemp, John P., Lachance, Genevieve, Lawson, Daniel, Lek, Monkol, Lopes, Margarida, MacArthur, Daniel G., Marchini, Jonathan, Massimo, Mangino, Mathieson, Iain, McCarthy, Shane, Memari, Yasin, Metrustry, Sarah, Min, Josine L., Moayyeri, Alireza, Muddyman, Dawn, Northstone, Kate, Panoutsopoulou, Kalliope, Paternoster, Lavinia, Perry, John R. B., Quaye, Lydia, Richards, J. Brent, Ring, Susan, Ritchie, Graham R. S., Schiffels, Stephan, Shihab, Hashem A., Shin, So-Youn, Small, Kerrin S., Artigas, Maria Soler, Soranzo, Nicole, Southam, Lorraine, Spector, Timothy D., St Pourcain, Beate, Surdulescu, Gabriela, Tachmazidou, Ioanna, Timpson, Nicholas J., Tobin, Martin D., Valdes, Ana M., Visscher, Peter M., Wain, Louise V., Walter, Klaudia, Ward, Kirsten, Wilson, Scott G., Wong, Kim, Yang, Jian, Zeggini, Eleftheria, Zhang, Feng, Zheng, Hou-Feng, Anney, Richard, Ayub, Muhammad, Barrett, Jeffrey C., Blackwood, Douglas, Bolton, Patrick F., Breen, Gerome, Collier, David A., Craddock, Nick, Crooks, Lucy, Curran, Sarah, Curtis, David, Durbin, Richard, Gallagher, Louise, Geschwind, Daniel, Gurling, Hugh, Holmans, Peter, Lee, Irene, Lonnqvist, Jouko, McCarthy, Shane, McGuffin, Peter, McIntosh, Andrew M., McKechanie, Andrew G., McQuillin, Andrew ORCID: 0000-0003-1567-2240, Morris, James, Muddyman, Dawn, O'Donovan, Michael C., Owen, Michael J., Palotie, Aarno, Parr, Jeremy R., Paunio, Tiina, Pietilainen, Olli, Rehnstrom, Karola, Sharp, Sally I., Skuse, David, St Clair, David, Suvisaari, Jaana, Walters, James T. R., Williams, Hywel J., Bochukova, Elena ORCID: 0000-0003-0275-1548, Bounds, Rebecca, Dominiczak, Anna, Durbin, Richard, Keogh, Julia, Marenne, Gaelle, McCarthy, Shane, Morris, Andrew, Muddyman, Dawn, Porteous, David J., Smith, Blair H., Tachmazidou, Ioanna, Wheeler, Eleanor, Zeggini, Eleftheria, Al Turki, Saeed, Anderson, Carl A., Antony, Dinu, Beales, Phil, Bentham, Jamie, Bhattacharya, Shoumo, Calissano, Mattia, Carss, Keren, Chatterjee, Krishna, Cirak, Sebahattin, Cosgrove, Catherine, Durbin, Richard, Fitzpatrick, David R., Floyd, James, Foley, A. Reghan, Franklin, Christopher S., Futema, Marta, Grozeva, Detelina, Humphries, Steve E., Hurles, Matthew E., McCarthy, Shane, Mitchison, Hannah M., Muddyman, Dawn, Muntoni, Francesco, Onoufriadis, Alexandros, Parker, Victoria, Payne, Felicity, Plagnol, Vincent, Raymond, F. Lucy, Roberts, Nicola, Savage, David B., Scambler, Peter, Schmidts, Miriam, Schoenmakers, Nadia, Semple, Robert K., Serra, Eva, Spasic-Boskovic, Olivera, Stevens, Elizabeth, van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Walter, Klaudia, Williamson, Kathleen A., Wilson, Crispian, Whyte, Tamieka, Ciampi, Antonio, Greenwood, Celia M. T., Li, Rui, Metrustry, Sarah, Oualkacha, Karim, Tachmazidou, Ioanna, Xu, ChangJiang, Zeggini, Eleftheria, Bobrow, Martin, Bolton, Patrick F., Durbin, Richard, Fitzpatrick, David R., Griffin, Heather, Hurles, Matthew E., Kaye, Jane, Kennedy, Karen, Kent, Alastair, Muddyman, Dawn, Muntoni, Francesco, Raymond, F. Lucy, Semple, Robert K., Smee, Carol, Spector, Timothy D., Timpson, Nicholas J., Charlton, Ruth, Ekong, Rosemary, Futema, Marta, Humphries, Steve E., Khawaja, Farrah, Lopes, Luis R., Migone, Nicola, Payne, Stewart J., Plagnol, Vincent, Pollitt, Rebecca C., Povey, Sue, Ridout, Cheryl K., Robinson, Rachel L., Scott, Richard H., Shaw, Adam, Syrris, Petros, Taylor, Rohan, Vandersteen, Anthony M., Barrett, Jeffrey C., Smith, George Davey ORCID: 0000-0002-1407-8314, Durbin, Richard, Fitzpatrick, David R., Hurles, Matthew E., Kaye, Jane, Kennedy, Karen, Langford, Cordelia, McCarthy, Shane, Muddyman, Dawn, Owen, Michael J., Palotie, Aarno, Richards, J. Brent, Soranzo, Nicole, Spector, Timothy D., Stalker, Jim, Timpson, Nicholas J., Zeggini, Eleftheria, Amuzu, Antoinette, Casas, Juan Pablo, Chambers, John C., Cocca, Massimiliano, Dedoussis, George, Gambaro, Giovanni, Gasparini, Paolo, Gaunt, Tom R., Huang, Jie, Iotchkova, Valentina, Isaacs, Aaron, Johnson, Jon, Kleber, Marcus E., Kooner, Jaspal S., Langenberg, Claudia, Luan, Jian'an, Malerba, Giovanni, Marz, Winfried, Matchan, Angela, Min, Josine L., Morris, Richard, Nordestgaard, Borge G., Benn, Marianne, Ring, Susan, Scott, Robert A., Soranzo, Nicole, Southam, Lorraine, Timpson, Nicholas J., Toniolo, Daniela ORCID: 0000-0001-9545-6032, Traglia, Michela, Tybjaerg-Hansen, Anne, van Duijn, Cornelia M., van Leeuwen, Elisabeth M., Varbo, Anette, Whincup, Peter, Zaza, Gianluigi, Zeggini, Eleftheria and Zhang, Weihua (2019). Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function human variant (SRC-1L1376P), leptin-induced depolarization of Pomc neurons and Pomc expression are significantly reduced, and food intake and body weight are increased. In summary, we demonstrate that SRC-1 modulates the function of hypothalamic Pomc neurons, and suggest that targeting SRC-1 may represent a useful therapeutic strategy for weight loss.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yang, Yongjie UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Klaauw, Agatha A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhu, Liangru UNSPECIFIED UNSPECIFIED UNSPECIFIED Cacciottolo, Tessa M. UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Yanlin UNSPECIFIED orcid.org/0000-0002-5471-9016 UNSPECIFIED Stadler, Lukas K. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Chunmei UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Pingwen UNSPECIFIED UNSPECIFIED UNSPECIFIED Saito, Kenji UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinton, Antentor UNSPECIFIED UNSPECIFIED UNSPECIFIED Yan, Xiaofeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Keogh, Julia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Henning, Elana UNSPECIFIED UNSPECIFIED UNSPECIFIED Banton, Matthew C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hendricks, Audrey E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bochukova, Elena G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mistry, Vanisha UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawler, Katherine L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, Lan UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Jianming UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Rahilly, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Tong, Qingchun UNSPECIFIED orcid.org/0000-0002-4561-2540 UNSPECIFIED Barroso, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Malley, Bert W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Farooqi, I. Sadaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Yong UNSPECIFIED UNSPECIFIED UNSPECIFIED Balasubramanian, Senduran UNSPECIFIED UNSPECIFIED UNSPECIFIED Clapham, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Coates, Guy UNSPECIFIED UNSPECIFIED UNSPECIFIED Cox, Tony UNSPECIFIED UNSPECIFIED UNSPECIFIED Daly, Allan UNSPECIFIED UNSPECIFIED UNSPECIFIED Danecek, Petr UNSPECIFIED UNSPECIFIED UNSPECIFIED Du, Yuanping UNSPECIFIED UNSPECIFIED UNSPECIFIED Durbin, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Edkins, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellis, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Flicek, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Guo, Xiaosen UNSPECIFIED UNSPECIFIED UNSPECIFIED Guo, Xueqin UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Liren UNSPECIFIED UNSPECIFIED UNSPECIFIED Jackson, David K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Joyce, Chris UNSPECIFIED UNSPECIFIED UNSPECIFIED Keane, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolb-Kokocinski, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Langford, Cordelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Yingrui UNSPECIFIED UNSPECIFIED UNSPECIFIED Liang, Jieqin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Hong UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Ryan UNSPECIFIED UNSPECIFIED UNSPECIFIED Maslen, John UNSPECIFIED UNSPECIFIED UNSPECIFIED McCarthy, Shane UNSPECIFIED UNSPECIFIED UNSPECIFIED Muddyman, Dawn UNSPECIFIED UNSPECIFIED UNSPECIFIED Quail, Michael A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stalker, Jim UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Jianping UNSPECIFIED UNSPECIFIED UNSPECIFIED Tian, Jing UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Guangbiao UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Wong, Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Pingbo UNSPECIFIED UNSPECIFIED UNSPECIFIED Birney, Ewan UNSPECIFIED UNSPECIFIED UNSPECIFIED Boustred, Chris UNSPECIFIED UNSPECIFIED UNSPECIFIED Brion, Marie-Jo UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Lu UNSPECIFIED UNSPECIFIED UNSPECIFIED Clement, Gail UNSPECIFIED UNSPECIFIED UNSPECIFIED Danecek, Petr UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, George Davey UNSPECIFIED orcid.org/0000-0002-1407-8314 UNSPECIFIED Day, Ian N. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Day-Williams, Aaron UNSPECIFIED UNSPECIFIED UNSPECIFIED Down, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunham, Ian UNSPECIFIED UNSPECIFIED UNSPECIFIED Durbin, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Evans, David M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fatemifar, Ghazaleh UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaunt, Tom R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geihs, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Greenwood, Celia M. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hart, Deborah UNSPECIFIED UNSPECIFIED UNSPECIFIED Howie, Bryan UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Jie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hubbard, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Hysi, Pirro UNSPECIFIED UNSPECIFIED UNSPECIFIED Iotchkova, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Jamshidi, Yalda UNSPECIFIED orcid.org/0000-0003-0151-6482 UNSPECIFIED Kemp, John P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lachance, Genevieve UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawson, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Lek, Monkol UNSPECIFIED UNSPECIFIED UNSPECIFIED Lopes, Margarida UNSPECIFIED UNSPECIFIED UNSPECIFIED MacArthur, Daniel G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marchini, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Massimo, Mangino UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathieson, Iain UNSPECIFIED UNSPECIFIED UNSPECIFIED McCarthy, Shane UNSPECIFIED UNSPECIFIED UNSPECIFIED Memari, Yasin UNSPECIFIED UNSPECIFIED UNSPECIFIED Metrustry, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Min, Josine L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moayyeri, Alireza UNSPECIFIED UNSPECIFIED UNSPECIFIED Muddyman, Dawn UNSPECIFIED UNSPECIFIED UNSPECIFIED Northstone, Kate UNSPECIFIED UNSPECIFIED UNSPECIFIED Panoutsopoulou, Kalliope UNSPECIFIED UNSPECIFIED UNSPECIFIED Paternoster, Lavinia UNSPECIFIED UNSPECIFIED UNSPECIFIED Perry, John R. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaye, Lydia UNSPECIFIED UNSPECIFIED UNSPECIFIED Richards, J. Brent UNSPECIFIED UNSPECIFIED UNSPECIFIED Ring, Susan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritchie, Graham R. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffels, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Shihab, Hashem A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shin, So-Youn UNSPECIFIED UNSPECIFIED UNSPECIFIED Small, Kerrin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Artigas, Maria Soler UNSPECIFIED UNSPECIFIED UNSPECIFIED Soranzo, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Southam, Lorraine UNSPECIFIED UNSPECIFIED UNSPECIFIED Spector, Timothy D. UNSPECIFIED UNSPECIFIED UNSPECIFIED St Pourcain, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Surdulescu, Gabriela UNSPECIFIED UNSPECIFIED UNSPECIFIED Tachmazidou, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Timpson, Nicholas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tobin, Martin D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Valdes, Ana M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visscher, Peter M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wain, Louise V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Klaudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Ward, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilson, Scott G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wong, Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Jian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeggini, Eleftheria UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Hou-Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Anney, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Ayub, Muhammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Barrett, Jeffrey C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blackwood, Douglas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bolton, Patrick F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Breen, Gerome UNSPECIFIED UNSPECIFIED UNSPECIFIED Collier, David A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Craddock, Nick UNSPECIFIED UNSPECIFIED UNSPECIFIED Crooks, Lucy UNSPECIFIED UNSPECIFIED UNSPECIFIED Curran, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Curtis, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Durbin, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Gallagher, Louise UNSPECIFIED UNSPECIFIED UNSPECIFIED Geschwind, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gurling, Hugh UNSPECIFIED UNSPECIFIED UNSPECIFIED Holmans, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Lonnqvist, Jouko UNSPECIFIED UNSPECIFIED UNSPECIFIED McCarthy, Shane UNSPECIFIED UNSPECIFIED UNSPECIFIED McGuffin, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED McIntosh, Andrew M. UNSPECIFIED UNSPECIFIED UNSPECIFIED McKechanie, Andrew G. UNSPECIFIED UNSPECIFIED UNSPECIFIED McQuillin, Andrew UNSPECIFIED orcid.org/0000-0003-1567-2240 UNSPECIFIED Morris, James UNSPECIFIED UNSPECIFIED UNSPECIFIED Muddyman, Dawn UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Donovan, Michael C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Owen, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Palotie, Aarno UNSPECIFIED UNSPECIFIED UNSPECIFIED Parr, Jeremy R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paunio, Tiina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pietilainen, Olli UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehnstrom, Karola UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharp, Sally I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Skuse, David UNSPECIFIED UNSPECIFIED UNSPECIFIED St Clair, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Suvisaari, Jaana UNSPECIFIED UNSPECIFIED UNSPECIFIED Walters, James T. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Hywel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bochukova, Elena UNSPECIFIED orcid.org/0000-0003-0275-1548 UNSPECIFIED Bounds, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Dominiczak, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Durbin, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Keogh, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Marenne, Gaelle UNSPECIFIED UNSPECIFIED UNSPECIFIED McCarthy, Shane UNSPECIFIED UNSPECIFIED UNSPECIFIED Morris, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Muddyman, Dawn UNSPECIFIED UNSPECIFIED UNSPECIFIED Porteous, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Blair H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tachmazidou, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Wheeler, Eleanor UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeggini, Eleftheria UNSPECIFIED UNSPECIFIED UNSPECIFIED Al Turki, Saeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Anderson, Carl A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antony, Dinu UNSPECIFIED UNSPECIFIED UNSPECIFIED Beales, Phil UNSPECIFIED UNSPECIFIED UNSPECIFIED Bentham, Jamie UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhattacharya, Shoumo UNSPECIFIED UNSPECIFIED UNSPECIFIED Calissano, Mattia UNSPECIFIED UNSPECIFIED UNSPECIFIED Carss, Keren UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatterjee, Krishna UNSPECIFIED UNSPECIFIED UNSPECIFIED Cirak, Sebahattin UNSPECIFIED UNSPECIFIED UNSPECIFIED Cosgrove, Catherine UNSPECIFIED UNSPECIFIED UNSPECIFIED Durbin, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Fitzpatrick, David R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Floyd, James UNSPECIFIED UNSPECIFIED UNSPECIFIED Foley, A. Reghan UNSPECIFIED UNSPECIFIED UNSPECIFIED Franklin, Christopher S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Futema, Marta UNSPECIFIED UNSPECIFIED UNSPECIFIED Grozeva, Detelina UNSPECIFIED UNSPECIFIED UNSPECIFIED Humphries, Steve E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hurles, Matthew E. UNSPECIFIED UNSPECIFIED UNSPECIFIED McCarthy, Shane UNSPECIFIED UNSPECIFIED UNSPECIFIED Mitchison, Hannah M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muddyman, Dawn UNSPECIFIED UNSPECIFIED UNSPECIFIED Muntoni, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Onoufriadis, Alexandros UNSPECIFIED UNSPECIFIED UNSPECIFIED Parker, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Payne, Felicity UNSPECIFIED UNSPECIFIED UNSPECIFIED Plagnol, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Raymond, F. Lucy UNSPECIFIED UNSPECIFIED UNSPECIFIED Roberts, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Savage, David B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scambler, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidts, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenmakers, Nadia UNSPECIFIED UNSPECIFIED UNSPECIFIED Semple, Robert K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Serra, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Spasic-Boskovic, Olivera UNSPECIFIED UNSPECIFIED UNSPECIFIED Stevens, Elizabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED van Kogelenberg, Margriet UNSPECIFIED UNSPECIFIED UNSPECIFIED Vijayarangakannan, Parthiban UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Klaudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Williamson, Kathleen A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilson, Crispian UNSPECIFIED UNSPECIFIED UNSPECIFIED Whyte, Tamieka UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciampi, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Greenwood, Celia M. T. 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UNSPECIFIED UNSPECIFIED UNSPECIFIED Smee, Carol UNSPECIFIED UNSPECIFIED UNSPECIFIED Spector, Timothy D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timpson, Nicholas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Charlton, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Ekong, Rosemary UNSPECIFIED UNSPECIFIED UNSPECIFIED Futema, Marta UNSPECIFIED UNSPECIFIED UNSPECIFIED Humphries, Steve E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khawaja, Farrah UNSPECIFIED UNSPECIFIED UNSPECIFIED Lopes, Luis R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Migone, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Payne, Stewart J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Plagnol, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Pollitt, Rebecca C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Povey, Sue UNSPECIFIED UNSPECIFIED UNSPECIFIED Ridout, Cheryl K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Robinson, Rachel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scott, Richard H. 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URN:	urn:nbn:de:hbz:38-150792
DOI:	10.1038/s41467-019-08737-6
Journal or Publication Title:	Nat. Commun.
Volume:	10
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEPTIN RESISTANCE; PROOPIOMELANOCORTIN NEURONS; SIGNAL TRANSDUCER; SOCS-3 EXPRESSION; FOOD-INTAKE; PPAR-GAMMA; ER STRESS; OBESITY; BALANCE; FOXO1 Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15079