Seleznova, Yana ORCID: 0000-0001-7260-6384, Brass, Patrick, Hellmich, Martin ORCID: 0000-0001-5174-928X, Stock, Stephanie ORCID: 0000-0002-1726-9300 and Mueller, Dirk (2019). Cost-effectiveness-analysis of ultrasound guidance for central venous catheterization compared with landmark method: a decision-analytic model. BMC Anesthesiol., 19. LONDON: BMC. ISSN 1471-2253

Full text not available from this repository.


Background: Ultrasound guidance for central venous catheterization is a commonly used alternative to the conventional landmark method. Because from the German perspective, the cost-effectiveness of ultrasound guidance is unclear, this study examined the cost-effectiveness of ultrasound guidance versus the landmark method for adults undergoing a central venous catheterization. Methods: A decision-tree based model was built to estimate the costs of averted catheter-related complications. Clinical data (e.g. arterial puncture, failed attempts) were obtained from a Cochrane review and a randomized controlled trial, whilst information about cost parameters were taken from a German hospital of maximum care. The analysis was conducted from the perspective of the German Statutory Health Insurance. Results were presented as incremental cost-effectiveness ratios. To assess the parameter uncertainty, several sensitivity analyses were performed (deterministic, probabilistic and with regard to the model structure). Results: Our analysis revealed that ultrasound guidance resulted in fewer complications per person (0.04 versus 0.17 for the landmark method) and was less expensive ((sic)51 versus (sic)230 for the landmark method). Results were robust to changes in the model parameters and in the model structure. Whilst our model population reflected approximately 49% of adults undergoing a central venous catheterization cannulation per year, structural sensitivity analyses (e.g. extending the study cohort to patients at higher baseline risk of complications, pediatric patients, or using real-time/indirect catheterization) indicated the cost-effectiveness of ultrasound guidance for a broader spectrum of patients. The results should be interpreted by considering the assumptions (e.g. target population) and approximations (e.g. cost parameters) underpinning the model. Conclusions: Ultrasound guidance for central venous catheterization averts more catheter-related complications and may save the resources of the German Statutory Health Insurance compared with landmark method.

Item Type: Journal Article
CreatorsEmailORCIDORCID Put Code
URN: urn:nbn:de:hbz:38-150851
DOI: 10.1186/s12871-019-0719-5
Journal or Publication Title: BMC Anesthesiol.
Volume: 19
Date: 2019
Publisher: BMC
Place of Publication: LONDON
ISSN: 1471-2253
Language: English
Faculty: Faculty of Medicine
Divisions: Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects: Medical sciences Medicine
Uncontrolled Keywords:
AnesthesiologyMultiple languages
Refereed: Yes


Downloads per month over past year



Actions (login required)

View Item View Item