Universität zu Köln

John, Uwe ORCID: 0000-0002-1297-4086, Lu, Yameng ORCID: 0000-0001-9682-4407, Wohlrab, Sylke ORCID: 0000-0003-3190-0880, Groth, Marco ORCID: 0000-0002-9199-8990, Janouskovec, Jan ORCID: 0000-0001-6547-749X, Kohli, Gurjeet S., Mark, Felix C., Bickmeyer, Ulf ORCID: 0000-0002-5351-2902, Farhat, Sarah ORCID: 0000-0001-7725-2589, Felder, Marius, Frickenhaus, Stephan, Guillou, Laure, Keeling, Patrick J., Moustafa, Ahmed ORCID: 0000-0002-0111-3555, Porcel, Betina M., Valentin, Klaus and Gloeckner, Gernot (2019). An aerobic eukaryotic parasite with functional mitochondria that likely lacks a mitochondrial genome. Sci. Adv., 5 (4). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

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Abstract

Dinoflagellates are microbial eukaryotes that have exceptionally large nuclear genomes; however, their organelle genomes are small and fragmented and contain fewer genes than those of other eukaryotes. The genus Amoebophrya (Syndiniales) comprises endoparasites with high genetic diversity that can infect other dinoflagellates, such as those forming harmful algal blooms (e.g., Alexandrium). We sequenced the genome (similar to 100 Mb) of Amoebophrya ceratii to investigate the early evolution of genomic characters in dinoflagellates. The A. ceratii genome encodes almost all essential biosynthetic pathways for self-sustaining cellular metabolism, suggesting a limited dependency on its host. Although dinoflagellates are thought to have descended from a photosynthetic ancestor, A. ceratii appears to have completely lost its plastid and nearly all genes of plastid origin. Functional mitochondria persist in all life stages of A. ceratii, but we found no evidence for the presence of a mitochondrial genome. Instead, all mitochondrial proteins appear to be lost or encoded in the A. ceratii nucleus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code John, Uwe UNSPECIFIED orcid.org/0000-0002-1297-4086 UNSPECIFIED Lu, Yameng UNSPECIFIED orcid.org/0000-0001-9682-4407 UNSPECIFIED Wohlrab, Sylke UNSPECIFIED orcid.org/0000-0003-3190-0880 UNSPECIFIED Groth, Marco UNSPECIFIED orcid.org/0000-0002-9199-8990 UNSPECIFIED Janouskovec, Jan UNSPECIFIED orcid.org/0000-0001-6547-749X UNSPECIFIED Kohli, Gurjeet S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mark, Felix C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickmeyer, Ulf UNSPECIFIED orcid.org/0000-0002-5351-2902 UNSPECIFIED Farhat, Sarah UNSPECIFIED orcid.org/0000-0001-7725-2589 UNSPECIFIED Felder, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Frickenhaus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Guillou, Laure UNSPECIFIED UNSPECIFIED UNSPECIFIED Keeling, Patrick J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moustafa, Ahmed UNSPECIFIED orcid.org/0000-0002-0111-3555 UNSPECIFIED Porcel, Betina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Valentin, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Gloeckner, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-151573
DOI:	10.1126/sciadv.aav1110
Journal or Publication Title:	Sci. Adv.
Volume:	5
Number:	4
Date:	2019
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	2375-2548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SHIKIMATE PATHWAY; DINOFLAGELLATE; DIVERSITY; EVOLUTION; GENES; APICOMPLEXAN Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15157