Universität zu Köln

Haidl, Gerhard, Haidl, Friederike, Allam, Jean-Pierre and Schuppe, Hans-Christian ORCID: 0000-0002-0874-0439 (2019). Therapeutic options in male genital tract inflammation. Andrologia, 51 (3). HOBOKEN: WILEY. ISSN 1439-0272

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Abstract

Chronic inflammatory conditions of the genital tract are still unsatisfactorily recognised in the workup of male infertility due to inappropriate definitions and inconsistent diagnostic criteria. The most popular term used for description of both, infections and inflammation in the genital tract is MAGI (male accessory gland infection). In asymptomatic patients, the diagnosis is primarily based on leucocytospermia (i.e., more than 1 million peroxidase-positive leucocytes per ml ejaculate), although ongoing infections should be identified and distinguished from post-infectious or non-infectious inflammatory disease. In addition to alterations of the basic semen parameters, sperm functions -and DNA integrity may be affected by chronic inflammation of the male genital tract. Despite considerable diagnostic drawbacks and a rather limited database concerning evidence-based therapy, adequate management of affected patients appears mandatory. Antibiotic treatment aims at the eradication or reduction of pathogenic bacteria in the ejaculate. Available studies suggest, that NSAID are effective in chronic inflammatory conditions. Moreover, low-dose corticosteroids, mast cell blockers, and other immune-modulatory compounds as well as a sequential adjuvant treatment with antioxidants can be considered as therapeutic options.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haidl, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Allam, Jean-Pierre UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuppe, Hans-Christian UNSPECIFIED orcid.org/0000-0002-0874-0439 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-153155
DOI:	10.1111/and.13207
Journal or Publication Title:	Andrologia
Volume:	51
Number:	3
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0272
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR-ALPHA; MAST-CELL BLOCKER; ACCESSORY-GLAND INFECTION; SPERM DNA FRAGMENTATION; IN-VITRO FERTILIZATION; MALE-INFERTILITY; SEMINAL PLASMA; DOUBLE-BLIND; UROGENITAL INFECTIONS; OXIDATIVE STRESS Multiple languages Andrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15315