Universität zu Köln

Vinken, Lore, Fransen, Katrien, Cuypers, Lize, Alexiev, Ivailo, Balotta, Claudia, Debaisieux, Laurent, Seguin-Devaux, Carole ORCID: 0000-0003-0636-5222, Ribas, Sergio Garcia, Gomes, Perpetua, Incardona, Francesca, Kaiser, Rolf, Ruelle, Jean, Sayan, Murat ORCID: 0000-0002-4374-7193, Paraschiv, Simona, Paredes, Roger, Peeters, Martine, Sonnerborg, Anders ORCID: 0000-0001-8928-3374, Vancutsem, Ellen, Vandamme, Anne-Mieke, Van den Wijngaert, Sigi, Van Ranst, Marc ORCID: 0000-0002-1674-4157, Verhofstede, Chris, Stadler, Tanja ORCID: 0000-0001-6431-535X, Lemey, Philippe and Van Laethem, Kristel ORCID: 0000-0001-6036-2271 (2019). Earlier Initiation of Antiretroviral Treatment Coincides With an Initial Control of the HIV-1 Sub-Subtype F1 Outbreak Among Men-Having-Sex-With-Men in Flanders, Belgium. Front. Microbiol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-302X

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Abstract

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, the Belgian AIDS Reference Laboratories collected HIV-1 pol sequences from all subsubtype F1-infected patients for whom genotypic drug resistance testing was requested as part of routine clinical follow-up. This data was complemented with HIV-1 pol sequences from countries with a high burden of F1 infections or a potential role in the global origin of sub-subtype F1. The molecular epidemiology of the Belgian subtype F1 epidemic was investigated using Bayesian phylogenetic inference and transmission dynamics were characterized based on birth-death models. F1 sequences were retained from 297 patients diagnosed and linked to care in Belgium between 1988 and 2015. Phylogenetic inference indicated that among the 297 Belgian F1 sequences, 191 belonged to a monophyletic group that mainly contained sequences from people likely infected in Belgium (OR 26.67, 95% CI 9.59-74.15), diagnosed in Flanders (OR 7.28, 95% CI 4.23-12.53), diagnosed at a recent stage of infection (OR 7.19, 95% CI 2.88-17.95) or declared to be MSM (OR 34.8, 95% CI 16.0-75.6). Together with a Spanish clade, this Belgian clade was embedded in the genetic diversity of Brazilian subtype F1 strains and most probably emerged after one or only a few migration events from Brazil to the European continent before 2002. The origin of the Belgian outbreak was dated back to 2002 (95% higher posterior density 2000-2004) and birth-death models suggested that its extensive growth had been controlled (R-e < 1) by 2012, coinciding with a time period where delay in antiretroviral treatment initiation substantially declined. In conclusion, phylogenetic reconstruction of the Belgian HIV-1 sub-subtype F1 epidemic illustrates the introduction and substantial dissemination of viral strains in a geographically restricted risk group that was most likely controlled by effective treatment as prevention.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vinken, Lore UNSPECIFIED UNSPECIFIED UNSPECIFIED Fransen, Katrien UNSPECIFIED UNSPECIFIED UNSPECIFIED Cuypers, Lize UNSPECIFIED UNSPECIFIED UNSPECIFIED Alexiev, Ivailo UNSPECIFIED UNSPECIFIED UNSPECIFIED Balotta, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Debaisieux, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED Seguin-Devaux, Carole UNSPECIFIED orcid.org/0000-0003-0636-5222 UNSPECIFIED Ribas, Sergio Garcia UNSPECIFIED UNSPECIFIED UNSPECIFIED Gomes, Perpetua UNSPECIFIED UNSPECIFIED UNSPECIFIED Incardona, Francesca UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruelle, Jean UNSPECIFIED UNSPECIFIED UNSPECIFIED Sayan, Murat UNSPECIFIED orcid.org/0000-0002-4374-7193 UNSPECIFIED Paraschiv, Simona UNSPECIFIED UNSPECIFIED UNSPECIFIED Paredes, Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED Peeters, Martine UNSPECIFIED UNSPECIFIED UNSPECIFIED Sonnerborg, Anders UNSPECIFIED orcid.org/0000-0001-8928-3374 UNSPECIFIED Vancutsem, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Vandamme, Anne-Mieke UNSPECIFIED UNSPECIFIED UNSPECIFIED Van den Wijngaert, Sigi UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Ranst, Marc UNSPECIFIED orcid.org/0000-0002-1674-4157 UNSPECIFIED Verhofstede, Chris UNSPECIFIED UNSPECIFIED UNSPECIFIED Stadler, Tanja UNSPECIFIED orcid.org/0000-0001-6431-535X UNSPECIFIED Lemey, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Laethem, Kristel UNSPECIFIED orcid.org/0000-0001-6036-2271 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-153381
DOI:	10.3389/fmicb.2019.00613
Journal or Publication Title:	Front. Microbiol.
Volume:	10
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-302X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRUG-RESISTANCE; NON-B; NORTHWEST SPAIN; BLOOD-DONORS; PREVALENCE; EPIDEMIC; DIVERSITY; THERAPY; MUTATIONS; STRAINS Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15338