Weiss, Michael, Michels, Guido, Eberhardt, Frank, Fehske, Wolfgang, Winter, Stefan, Baer, Frank, Choi, Yeong-Hoon, Albus, Christian, Steven, Daniel, Baldus, Stephan and Pfister, Roman (2019). Anxiety, depression and quality of life in acute high risk cardiac disease patients eligible for wearable cardioverter defibrillator: Results from the prospective multicenter CRED-registry. PLoS One, 14 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background Psychological distress is common in patients with cardiovascular disease and negatively impacts outcome. Hypothesis Psychological distress is high in acute high risk cardiac patients eligible for a WCD, and associated with low quality of life. Distress is aggravated by WCD. Methods Consecutive patients eligible for a WCD were included in the prospective, multicenter Cologne Registry of External Defibrillator registry. Quality of life (Short Form-12), depressive symptoms (Beck-Depression Inventory II) and anxiety (State Trait Anxiety Inventory) were assessed at enrollment and 6-weeks, and associations with WCD prescription were analyzed. Results 123 patients (mean [SD] age 59 [+/- 14] years, 75% male) were included, 85 (69%) of whom received a WCD. At enrollment 21% showed clinically significant depressive symptoms and 52% anxiety symptoms, respectively. At 6 weeks, depressive and anxious symptoms significantly decreased to 7% and 25%, respectively. Depressive symptoms at enrollment and changes at 6 weeks showed significant associations with health-related quality of life, whereas anxious symptoms did not. There was a trend for better improvement of depression scores in patients with WCD (mean [SD] change in score points: -4.1 [6.1] vs -1.8 [3.9]; p = 0.09), whereas change of the anxiousness score was not different (-4.6 [9.5]) vs -3.7 [9.1], p = 0.68). Conclusion In patients eligible for a WCD, depressive and anxiety symptoms were initially common and depressive symptoms showed a strong association with reduced health-related quality of life contributing to their clinical relevance. WCD recipients showed at least similar improvement of depression and anxiety at 6 weeks when compared to non recipients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Weiss, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberhardt, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehske, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winter, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baer, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choi, Yeong-HoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albus, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steven, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-153955
DOI: 10.1371/journal.pone.0213261
Journal or Publication Title: PLoS One
Volume: 14
Number: 3
Date: 2019
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEART-FAILURE; SYMPTOMS; INTERVENTION; OUTPATIENTS; MORTALITY; IMPACTMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15395

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