Universität zu Köln

Mielke, Orell, Bril, Vera, Cornblath, David R., Lawo, John-Philip, van Geloven, Nan, Hartung, Hans-Peter, Lewis, Richard A., Merkies, Ingemar S. J., Sobue, Gen, Durn, Billie, Shebl, Amgad, van Schaik, Ivo N., Sabet, A., George, K., Roberts, L., Carne, R., Blum, S., Henderson, R., Van Damme, P., Demeestere, J., Larue, S., D'Amour, C., Kunc, P., Valis, M., Sussova, J., Kalous, T., Talab, R., Bednar, M., Toomsoo, T., Rubanovits, I., Gross-Paju, K., Sorro, U., Saarela, M., Auranen, M., Pouget, J., Attarian, S., Le Masson, G., Wielanek-Bachelet, A., Desnuelle, C., Delmont, E., Clavelou, P., Aufauvre, D., Schmidt, J., Zschuentzsch, J., Sommer, C., Kramer, D., Hoffmann, O., Goerlitz, C., Haas, J., Chatzopoulos, M., Yoon, R., Gold, R., Berlit, P., Jaspert-Grehl, A., Liebetanz, D., Kutschenko, A., Stangel, M., Trebst, C., Baum, P., Bergh, F., Klehmet, J., Meisel, A., Klostermann, F., Oechtering, J., Lehmann, H., Schroeter, M., Hagenacker, T., Mueller, D., Sperfeld, A., Bethke, F., Drory, V., Algom, A., Yarnitsky, D., Murinson, B., Di Muzio, A., Ciccocioppo, F., Sorbi, S., Mata, S., Schenone, A., Grandis, M., Lauria, G., Cazzato, D., Antonini, G., Morino, S., Cocito, D., Zibetti, M., Yokota, T., Ohkubo, T., Kanda, T., Kawai, M., Kaida, K., Onoue, H., Kuwabara, S., Mori, M., Iijima, M., Ohyama, K., Baba, M., Tomiyama, M., Nishiyama, K., Akutsu, T., Yokoyama, K., Kanai, K., van Schaik, I. N., Eftimov, F., Notermans, N. C., Visser, N., Faber, C., Hoeijmakers, J., Rejdak, K., Chyrchel-Paszkiewicz, U., Casanovas Pons, C., Antonia, M., Gamez, J., Salvado, M., Marquez Infante, C., Benitez, S., Lunn, M., Morrow, J., Gosal, D., Lavin, T., Melamed, I., Testori, A., Ajroud-Driss, S., Menichella, D., Simpson, E., Lai, E. Chi-Ho, Dimachkie, M., Barohn, R. J., Beydoun, S., Johl, H., Lange, D., Shtilbans, A., Muley, S., Ladha, S., Freimer, M., Kissel, J., Latov, N., Chin, R., Ubogu, E., Mumfrey, S., Rao, T., MacDonald, P., Sharma, K., Gonzalez, G., Allen, J., Walk, D., Hobson-Webb, L. and Gable, K. (2019). Restabilization treatment after intravenous immunoglobulin withdrawal in chronic inflammatory demyelinating polyneuropathy: Results from the pre-randomization phase of the Polyneuropathy And Treatment with Hizentra study. J. Peripher. Nerv. Syst., 24 (1). S. 72 - 80. HOBOKEN: WILEY. ISSN 1529-8027

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Abstract

In patients with chronic inflammatory demyelinating polyneuropathy (CIDP), intravenous immunoglobulin (IVIG) is recommended to be periodically reduced to assess the need for ongoing therapy. However, little is known about the effectiveness of restabilization with IVIG in patients who worsen after IVIG withdrawal. In the Polyneuropathy And Treatment with Hizentra (PATH) study, the pre-randomization period included sudden stopping of IVIG followed by 12 weeks of observation. Those deteriorating were then restabilized with IVIG. Of 245 subjects who stopped IVIG, 28 did not show signs of clinical deterioration within 12 weeks. Two hundred and seven received IVIG restabilization with an induction dose of 2 g/kg bodyweight (bw) IgPro10 (Privigen, CSL Behring, King of Prussia, Pennsylvania) and maintenance doses of 1 g/kg bw every 3 weeks for up to 13 weeks. Signs of clinical improvement were seen in almost all (n = 188; 91%) subjects. During IVIG restabilization, 35 subjects either did not show CIDP stability (n = 21, analyzed as n = 22 as an additional subject was randomized in error) or withdrew for other reasons (n = 14). Of the 22 subjects who did not achieve clinical stability, follow-up information in 16 subjects after an additional 4 weeks was obtained. Nine subjects were reported to have improved, leaving a maximum of 27 subjects (13%) who either showed no signs of clinical improvement during the restabilization phase and 4 weeks post-study or withdrew for other reasons. In conclusion, sudden IVIG withdrawal was effective in detecting ongoing immunoglobulin G dependency with a small risk for subjects not returning to their baseline 17 weeks after withdrawal.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mielke, Orell UNSPECIFIED UNSPECIFIED UNSPECIFIED Bril, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornblath, David R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawo, John-Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED van Geloven, Nan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartung, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Richard A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkies, Ingemar S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sobue, Gen UNSPECIFIED UNSPECIFIED UNSPECIFIED Durn, Billie UNSPECIFIED UNSPECIFIED UNSPECIFIED Shebl, Amgad UNSPECIFIED UNSPECIFIED UNSPECIFIED van Schaik, Ivo N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabet, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED George, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roberts, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Carne, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blum, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Henderson, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Damme, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Demeestere, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Larue, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Amour, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunc, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Valis, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sussova, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalous, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Talab, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bednar, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toomsoo, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubanovits, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gross-Paju, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorro, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saarela, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Auranen, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pouget, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Attarian, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le Masson, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wielanek-Bachelet, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Desnuelle, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Delmont, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clavelou, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aufauvre, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zschuentzsch, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramer, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goerlitz, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatzopoulos, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yoon, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gold, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berlit, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaspert-Grehl, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebetanz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kutschenko, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stangel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Trebst, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baum, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergh, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klehmet, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klostermann, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oechtering, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagenacker, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sperfeld, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bethke, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drory, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Algom, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yarnitsky, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Murinson, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Muzio, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciccocioppo, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorbi, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mata, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenone, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandis, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lauria, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cazzato, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonini, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morino, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cocito, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zibetti, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yokota, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohkubo, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kanda, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kawai, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaida, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Onoue, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuwabara, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mori, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Iijima, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohyama, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baba, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tomiyama, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nishiyama, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Akutsu, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yokoyama, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kanai, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Schaik, I. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eftimov, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Notermans, N. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faber, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeijmakers, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rejdak, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chyrchel-Paszkiewicz, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Casanovas Pons, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonia, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gamez, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salvado, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marquez Infante, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Benitez, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lunn, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrow, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gosal, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lavin, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Melamed, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Testori, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ajroud-Driss, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Menichella, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simpson, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lai, E. Chi-Ho UNSPECIFIED UNSPECIFIED UNSPECIFIED Dimachkie, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barohn, R. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beydoun, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johl, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shtilbans, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muley, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ladha, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Freimer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kissel, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Latov, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chin, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ubogu, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mumfrey, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rao, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED MacDonald, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gonzalez, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allen, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walk, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hobson-Webb, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gable, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-155350
DOI:	10.1111/jns.12303
Journal or Publication Title:	J. Peripher. Nerv. Syst.
Volume:	24
Number:	1
Page Range:	S. 72 - 80
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1529-8027
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONTROLLED-TRIAL; POLYRADICULONEUROPATHY; METHYLPREDNISOLONE; STRENGTH; IVIG Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15535