Klement, Rainer J., Abbasi-Senger, N., Adebahr, S., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I., Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Krempien, R., Lewitzki, V., Lohaus, F., Ostheimer, C., Papachristofilou, A., Petersen, C., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Wachter, S., Wittig, A., Guckenberger, M. and Andratschke, N. (2019). The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases. BMC Cancer, 19. LONDON: BMC. ISSN 1471-2407

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Abstract

BackgroundThe aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.MethodsThe analysis is based on pooled data from two retrospective SBRT databases for pulmonary and hepatic metastases from 27 centers from Germany and Switzerland. Only patients with metastases from colorectal cancer were considered to avoid histology as a confounding factor. An illness-death model was employed to model the relationship between LC and OS.ResultsThree hundred eighty-eight patients with 500 metastatic lesions (lung n=209, liver n=291) were included and analyzed. Median follow-up time for local recurrence assessment was 12.1months. Ninety-nine patients with 112 lesions experienced local failure. Seventy-one of these patients died after local failure. Median survival time was 27.9months in all patients and 25.4months versus 30.6months in patients with and without local failure after SBRT. The baseline risk of death after local failure exceeds the baseline risk of death without local failure at 10months indicating better survival with LC.ConclusionIn CRC patients with lung or liver metastases, our findings suggest improved long-term OS by achieving metastatic disease control using SBRT in patients with a projected OS estimate of >12months.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Klement, Rainer J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abbasi-Senger, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adebahr, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alheid, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allgaeuer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blanck, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boda-Heggemann, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunner, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duma, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eble, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ernst, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerum, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habermehl, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hass, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henkenberens, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hildebrandt, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Imhoff, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahl, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klass, N. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krempien, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewitzki, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohaus, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostheimer, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papachristofilou, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petersen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieber, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrade, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Semrau, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachter, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittig, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guckenberger, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andratschke, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-156289
DOI: 10.1186/s12885-019-5362-5
Journal or Publication Title: BMC Cancer
Volume: 19
Date: 2019
Publisher: BMC
Place of Publication: LONDON
ISSN: 1471-2407
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RADIATION-THERAPY SBRT; PHASE I/II TRIAL; SUGGEST IMPLICATIONS; OLIGOMETASTASES; TUMORS; CHEMOTHERAPY; HISTOLOGY; DEATHMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15628

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