Universität zu Köln

Wojtala, Jennifer, Heber, Ines Ann, Neuser, Petra, Heller, Julia, Kalbe, Elke, Rehberg, Sarah P., Storch, Alexander, Linse, Katharina, Schneider, Christine, Graeber, Susanne, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Rudiger, Oberschmidt, Carola, Baudrexel, Simon, Witt, Karsten, Schmidt, Nele, Deuschl, Guenther, Mollenhauer, Brit, Trenkwalder, Claudia, Liepelt-Scarfone, Inga, Spottke, Annika, Roeske, Sandra, Wuellner, Ullrich, Wittchen, Hans-Ulrich, Riedel, Oliver, Dodel, Richard, Schulz, Joerg B. and Reetz, Kathrin (2019). Cognitive decline in Parkinson's disease: the impact of the motor phenotype on cognition. J. Neurol. Neurosurg. Psychiatry, 90 (2). S. 171 - 180. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-330X

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Abstract

Objectives Parkinson's disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia. The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function. Methods Demographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome. Analyses were performed for all patients and for each diagnostic group separately, controlling for age, gender, education and disease duration. Results Compared with the tremor-dominant phenotype, akinetic-rigid patients performed worse in executive functions such as working memory (Wechsler Memory Scale-Revised backward; p= 0.012), formallexical word fluency (p= 0.043), card sorting (p= 0.006), attention (Trail Making Test version A; p= 0.024) and visuospatial abilities (Leistungsprufungssystem test 9; p= 0.006). Akinetic-rigid neuropsychological test scores for the executive and attentive domain correlated negatively with non-tremor motor scores. Covariate-adjusted binary logistic regression analyses showed significant odds for PD-mild cognitive impairment for not-determined as compared with tremor-dominant (OR= 3.198) and akinetic-rigid PD (OR= 2.059). The odds for PD-dementia were significant for akinetic-rigid as compared with tremor-dominant phenotype (OR= 8.314). Conclusion The three motor phenotypes of PD differ in cognitive performance, showing that cognitive deficits seem to be less severe in tremor-dominant PD. While these data are cross-sectional, longitudinal data are needed to shed more light on these differential findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wojtala, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Heber, Ines Ann UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuser, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Heller, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, Sarah P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Linse, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeber, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Dams, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Balzer-Geldsetzer, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker-Roggendorf, Rudiger UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberschmidt, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Baudrexel, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Nele UNSPECIFIED UNSPECIFIED UNSPECIFIED Deuschl, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, Brit UNSPECIFIED UNSPECIFIED UNSPECIFIED Trenkwalder, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeske, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuellner, Ullrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, Hans-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Joerg B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157013
DOI:	10.1136/jnnp-2018-319008
Journal or Publication Title:	J. Neurol. Neurosurg. Psychiatry
Volume:	90
Number:	2
Page Range:	S. 171 - 180
Date:	2019
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-330X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL DIAGNOSTIC-CRITERIA; DEMENTIA; IMPAIRMENT; DEFICITS; SUBTYPE; DOPAMINE Multiple languages Clinical Neurology; Psychiatry; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15701