Universität zu Köln

Enders, Philip ORCID: 0000-0002-9527-4957, Adler, Werner ORCID: 0000-0001-9791-5407, Kiessling, David ORCID: 0000-0003-4341-0256, Weber, Vincent, Schaub, Friederike, Hermann, Manuel M., Dietlein, Thomas, Cursiefen, Claus and Heindl, Ludwig M. (2019). Evaluation of two-dimensional Bruch's membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort. Acta Ophthalmol., 97 (1). S. 60 - 68. HOBOKEN: WILEY. ISSN 1755-3768

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Abstract

Purpose To characterize the two-dimensional parameter Bruch's membrane opening minimum rim area (BMO-MRA) in spectral domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) compared to minimum rim width (BMO-MRW) and retinal nerve fibre layer (RNFL) thickness in a large patient cohort. Methods Case-control, cross-sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD-OCT and confocal laser scanning tomography (CSLT), visual field testing and clinical examination. Morphometric ONH parameters, visual field function and diagnostic power were compared. Main outcome measures were SD-OCT-derived BMO-MRA, BMO-MRW, RNFL thickness and CSLT-derived rim area (DM-RA). Results Mean ONH area was 2.11 +/- 0.57 mm(2); mean BMO area was 1.89 +/- 0.45 mm(2). Correlation of mean deviation in visual field to morphometric parameters was rho = 0.70, (p < 0.001) for RNFL thickness, rho = 0.68 (p < 0.001) for BMO-MRA, rho = 0.66 (p < 0.001) for BMO-MRW. These correlations were not significantly different (p > 0.05), while DM-RA correlated significantly worse (rho = 0.55; p < 0.001). In receiver operating characteristics, the calculated area under the curve (AUC) and sensitivity at 90% specificity to differentiate glaucoma were 0.87% and 70.1% for BMO-MRA, 0.86% and 68.1% for RNFL thickness, 0.84% and 66.0% for BMO-MRW, 0.82% and 51.3% for DM-RA. Conclusions In a heterogenous clinical cohort of glaucoma patients, all analysed SD-OCT parameters excel DM-RA of CSLT. The two-dimensional parameter BMO-MRA shows comparable levels of diagnostic power to detect glaucoma compared to established parameters BMO-MRW and RNFL thickness. Given higher comparability between ONH sizes, BMO-MRA might become an additional standard tool in SD-OCT imaging for glaucoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Adler, Werner UNSPECIFIED orcid.org/0000-0001-9791-5407 UNSPECIFIED Kiessling, David UNSPECIFIED orcid.org/0000-0003-4341-0256 UNSPECIFIED Weber, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Manuel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158111
DOI:	10.1111/aos.13698
Journal or Publication Title:	Acta Ophthalmol.
Volume:	97
Number:	1
Page Range:	S. 60 - 68
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1755-3768
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; NERVE-FIBER LAYER; SCANNING LASER OPHTHALMOSCOPY; SPECTRAL-DOMAIN OCT; DISC MARGIN ANATOMY; NEURORETINAL RIM; WIDTH; THICKNESS; HEAD Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15811