Haworth, Simon ORCID: 0000-0001-7793-7326, Shapland, Chin Yang, Hayward, Caroline ORCID: 0000-0002-9405-9550, Prins, Bram P., Felix, Janine F., Medina-Gomez, Carolina ORCID: 0000-0001-7999-5538, Rivadeneira, Fernando ORCID: 0000-0001-9435-9441, Wang, Carol, Ahluwalia, Tarunveer S., Vrijheid, Martine ORCID: 0000-0002-7090-1758, Guxens, Monica, Sunyer, Jordi ORCID: 0000-0002-2602-4110, Tachmazidou, Ioanna, Walter, Klaudia, Iotchkova, Valentina, Jackson, Andrew ORCID: 0000-0002-8739-2646, Cleal, Louise, Huffmann, Jennifer, Min, Josine L., Sass, Laerke ORCID: 0000-0002-5217-7014, Timmers, Paul R. H. J., Al Turki, Saeed, Anderson, Carl A., Anney, Richard, Antony, Dinu, Artigas, Maria Soler, Ayub, Muhammad, Bala, Senduran, Barrett, Jeffrey C., Barroso, Ines, Beales, Phil, Bentham, Jamie, Bhattacharya, Shoumo ORCID: 0000-0002-5571-0478, Birney, Ewan ORCID: 0000-0001-8314-8497, Blackwood, Douglas, Bobrow, Martin, Bochukova, Elena, Bolton, Patrick F., Bounds, Rebecca, Boustred, Chris, Breen, Gerome, Calissano, Mattia, Carss, Keren, Charlton, Ruth, Chatterjee, Krishna, Chen, Lu, Ciampi, Antonio, Cirak, Sebahattin, Clapham, Peter, Clement, Gail, Coates, Guy, Cocca, Massimiliano, Collier, David A., Cosgrove, Catherine, Cox, Tony, Craddock, Nick, Crooks, Lucy, Curran, Sarah, Curtis, David, Daly, Allan, Danecek, Petr, Day, Ian N. M., Day-Williams, Aaron, Dominiczak, Anna, Down, Thomas, Du, Yuanping, Dunham, Ian ORCID: 0000-0003-2525-5598, Durbin, Richard ORCID: 0000-0002-9130-1006, Edkins, Sarah, Ekong, Rosemary ORCID: 0000-0002-5984-7893, Ellis, Peter, Evans, David M., Farooqi, I. Sadaf, Fitzpatrick, David R., Flicek, Paul, Floyd, James, Foley, A. Reghan, Franklin, Christopher S., Futema, Marta, Gallagher, Louise ORCID: 0000-0001-9462-2836, Gaunt, Tom R., Geihs, Matthias, Geschwind, Daniel, Greenwood, Celia M. T., Griffin, Heather, Grozeva, Detelina, Guo, Xiaosen, Guo, Xueqin, Gurling, Hugh, Hart, Deborah, Hendricks, Audrey E., Holmans, Peter, Howie, Bryan, Huang, Jie, Huang, Liren, Hubbard, Tim, Humphries, Steve E., Hurles, Matthew E., Hysi, Pirro, Jackson, David K., Jamshidi, Yalda ORCID: 0000-0003-0151-6482, Joyce, Chris, Karczewski, Konrad J., Kaye, Jane ORCID: 0000-0002-7311-4725, Keane, Thomas, Kemp, John P., Kennedy, Karen, Kent, Alastair, Keogh, Julia, Khawaja, Farrah, van Kogelenberg, Margriet, Kolb-Kokocinski, Anja, Lachance, Genevieve, Langford, Cordelia, Lawson, Daniel ORCID: 0000-0002-5311-6213, Lee, Irene, Lek, Monkol, Li, Rui, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Lonnqvist, Jouko, Lopes, Luis R., Lopes, Margarida, MacArthur, Daniel G., Mangino, Massimo, Marchini, Jonathan, Marenne, Gaelle, Maslen, John, Mathieson, Iain, McCarthy, Shane, McGuffin, Peter, McIntosh, Andrew M., McKechanie, Andrew G., McQuillin, Andrew ORCID: 0000-0003-1567-2240, Memari, Yasin, Metrustry, Sarah, Migone, Nicola, Mitchison, Hannah M., Moayyeri, Alireza, Morris, Andrew, Morris, James, Muddyman, Dawn, Muntoni, Francesco, Northstone, Kate ORCID: 0000-0002-0602-1983, O'Donovan, Michael C., O'Rahilly, Stephen, Onoufriadis, Alexandros, Oualkacha, Karim, Owen, Michael J., Palotie, Aarno, Panoutsopoulou, Kalliope, Parker, Victoria, Parr, Jeremy R., Paternoster, Lavinia, Paunio, Tiina, Payne, Felicity, Payne, Stewart J., Perry, John R. B., Pietilainen, Olli, Plagnol, Vincent, Pollitt, Rebecca C., Porteous, David J., Povey, Sue, Quail, Michael A., Quaye, Lydia, Raymond, F. Lucy, Rehnstrom, Karola, Richards, J. Brent, Ridout, Cheryl K., Ring, Susan, Ritchie, Graham R. S., Roberts, Nicola, Robinson, Rachel L., Savage, David B., Scambler, Peter, Schiffels, Stephan, Schmidts, Miriam ORCID: 0000-0002-1714-6749, Schoenmakers, Nadia, Scott, Richard H., Semple, Robert K., Serra, Eva, Sharp, Sally I., Shaw, Adam, Shihab, Hashem A., Shin, So-Youn, Skuse, David, Small, Kerrin S., Smee, Carol, Smith, Blair H., Soranzo, Nicole, Southam, Lorraine, Spasic-Boskovic, Olivera, Spector, Timothy D., St Clair, David, Stalker, Jim, Stevens, Elizabeth, Sun, Jianping, Surdulescu, Gabriela, Suvisaari, Jaana, Syrris, Petros, Taylor, Rohan, Tian, Jing, Tobin, Martin D., Valdes, Ana M., Vandersteen, Anthony M., Vijayarangakannan, Parthiban, Visscher, Peter M., Wain, Louise V., Walters, James T. R., Wang, Guangbiao, Wang, Jun, Wang, Yu, Ward, Kirsten, Wheeler, Eleanor, Whyte, Tamieka, Williams, Hywel J., Williamson, Kathleen A., Wilson, Crispian, Wilson, Scott G., Wong, Kim, Xu, ChangJiang, Yang, Jian, Zhang, Feng, Zhang, Pingbo, Zheng, Hou-Feng, Smith, George Davey ORCID: 0000-0002-1407-8314, Fisher, Simon E. ORCID: 0000-0002-3132-1996, Wilson, James F., Cole, Tim J., Fernandez-Orth, Dietmar, Bonnelykke, Klaus, Bisgaard, Hans ORCID: 0000-0003-4131-7592, Pennell, Craig E., Jaddoe, Vincent W. V., Dedoussis, George, Timpson, Nicholas ORCID: 0000-0002-7141-9189, Zeggini, Eleftheria, Vitart, Veronique and St Pourcain, Beate ORCID: 0000-0002-4680-3517 (2019). Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determinants of ICV. Investigating up to 46,000 children and adults of European descent, we identify association with final HC and/or final ICV + HC at 9 novel common and low-frequency loci, illustrating that genetic variation from a wide allele frequency spectrum contributes to cranial growth. The largest effects are reported for low-frequency variants within TP53, with 0.5 cm wider heads in increaser-allele carriers versus non-carriers during mid-childhood, suggesting a previously unrecognized role of TP53 transcripts in human cranial development.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Haworth, SimonUNSPECIFIEDorcid.org/0000-0001-7793-7326UNSPECIFIED
Shapland, Chin YangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayward, CarolineUNSPECIFIEDorcid.org/0000-0002-9405-9550UNSPECIFIED
Prins, Bram P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Janine F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medina-Gomez, CarolinaUNSPECIFIEDorcid.org/0000-0001-7999-5538UNSPECIFIED
Rivadeneira, FernandoUNSPECIFIEDorcid.org/0000-0001-9435-9441UNSPECIFIED
Wang, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahluwalia, Tarunveer S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vrijheid, MartineUNSPECIFIEDorcid.org/0000-0002-7090-1758UNSPECIFIED
Guxens, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sunyer, JordiUNSPECIFIEDorcid.org/0000-0002-2602-4110UNSPECIFIED
Tachmazidou, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, KlaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iotchkova, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jackson, AndrewUNSPECIFIEDorcid.org/0000-0002-8739-2646UNSPECIFIED
Cleal, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huffmann, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Min, Josine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sass, LaerkeUNSPECIFIEDorcid.org/0000-0002-5217-7014UNSPECIFIED
Timmers, Paul R. H. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al Turki, SaeedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderson, Carl A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anney, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antony, DinuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Artigas, Maria SolerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ayub, MuhammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bala, SenduranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrett, Jeffrey C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barroso, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beales, PhilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bentham, JamieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhattacharya, ShoumoUNSPECIFIEDorcid.org/0000-0002-5571-0478UNSPECIFIED
Birney, EwanUNSPECIFIEDorcid.org/0000-0001-8314-8497UNSPECIFIED
Blackwood, DouglasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bobrow, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bochukova, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bolton, Patrick F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bounds, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boustred, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breen, GeromeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calissano, MattiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carss, KerenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Charlton, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chatterjee, KrishnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, LuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ciampi, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cirak, SebahattinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clapham, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clement, GailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coates, GuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cocca, MassimilianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collier, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosgrove, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, TonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Craddock, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crooks, LucyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curran, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curtis, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, AllanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danecek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Day, Ian N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Day-Williams, AaronUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominiczak, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Down, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Du, YuanpingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunham, IanUNSPECIFIEDorcid.org/0000-0003-2525-5598UNSPECIFIED
Durbin, RichardUNSPECIFIEDorcid.org/0000-0002-9130-1006UNSPECIFIED
Edkins, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekong, RosemaryUNSPECIFIEDorcid.org/0000-0002-5984-7893UNSPECIFIED
Ellis, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, David M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farooqi, I. SadafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fitzpatrick, David R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flicek, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Floyd, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foley, A. ReghanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franklin, Christopher S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Futema, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallagher, LouiseUNSPECIFIEDorcid.org/0000-0001-9462-2836UNSPECIFIED
Gaunt, Tom R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geihs, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geschwind, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenwood, Celia M. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griffin, HeatherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grozeva, DetelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guo, XiaosenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guo, XueqinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gurling, HughUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hart, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hendricks, Audrey E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmans, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Howie, BryanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, LirenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hubbard, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Humphries, Steve E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hurles, Matthew E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hysi, PirroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jackson, David K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamshidi, YaldaUNSPECIFIEDorcid.org/0000-0003-0151-6482UNSPECIFIED
Joyce, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karczewski, Konrad J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaye, JaneUNSPECIFIEDorcid.org/0000-0002-7311-4725UNSPECIFIED
Keane, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kemp, John P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kennedy, KarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kent, AlastairUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keogh, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khawaja, FarrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Kogelenberg, MargrietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolb-Kokocinski, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lachance, GenevieveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langford, CordeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lawson, DanielUNSPECIFIEDorcid.org/0000-0002-5311-6213UNSPECIFIED
Lee, IreneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lek, MonkolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, RuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, YingruiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liang, JieqinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lin, HongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, RyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lonnqvist, JoukoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopes, Luis R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopes, MargaridaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacArthur, Daniel G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mangino, MassimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchini, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marenne, GaelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maslen, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathieson, IainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McCarthy, ShaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuffin, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McIntosh, Andrew M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McKechanie, Andrew G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McQuillin, AndrewUNSPECIFIEDorcid.org/0000-0003-1567-2240UNSPECIFIED
Memari, YasinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metrustry, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Migone, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mitchison, Hannah M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moayyeri, AlirezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muddyman, DawnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muntoni, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Northstone, KateUNSPECIFIEDorcid.org/0000-0002-0602-1983UNSPECIFIED
O'Donovan, Michael C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Rahilly, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onoufriadis, AlexandrosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oualkacha, KarimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owen, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palotie, AarnoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panoutsopoulou, KalliopeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parker, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parr, Jeremy R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paternoster, LaviniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paunio, TiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Payne, FelicityUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Payne, Stewart J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perry, John R. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pietilainen, OlliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plagnol, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pollitt, Rebecca C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porteous, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Povey, SueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quail, Michael A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaye, LydiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raymond, F. LucyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rehnstrom, KarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richards, J. BrentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ridout, Cheryl K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ring, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritchie, Graham R. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roberts, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robinson, Rachel L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Savage, David B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scambler, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiffels, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidts, MiriamUNSPECIFIEDorcid.org/0000-0002-1714-6749UNSPECIFIED
Schoenmakers, NadiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, Richard H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Semple, Robert K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serra, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharp, Sally I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shaw, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shihab, Hashem A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shin, So-YounUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skuse, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Small, Kerrin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smee, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Blair H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soranzo, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southam, LorraineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spasic-Boskovic, OliveraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spector, Timothy D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
St Clair, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stalker, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stevens, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, JianpingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Surdulescu, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suvisaari, JaanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Syrris, PetrosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, RohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tian, JingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tobin, Martin D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valdes, Ana M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandersteen, Anthony M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vijayarangakannan, ParthibanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visscher, Peter M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wain, Louise V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walters, James T. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, GuangbiaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, YuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ward, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wheeler, EleanorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whyte, TamiekaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, Hywel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williamson, Kathleen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson, CrispianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson, Scott G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wong, KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xu, ChangJiangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, JianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, FengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, PingboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zheng, Hou-FengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, George DaveyUNSPECIFIEDorcid.org/0000-0002-1407-8314UNSPECIFIED
Fisher, Simon E.UNSPECIFIEDorcid.org/0000-0002-3132-1996UNSPECIFIED
Wilson, James F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cole, Tim J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez-Orth, DietmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonnelykke, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bisgaard, HansUNSPECIFIEDorcid.org/0000-0003-4131-7592UNSPECIFIED
Pennell, Craig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaddoe, Vincent W. V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dedoussis, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timpson, NicholasUNSPECIFIEDorcid.org/0000-0002-7141-9189UNSPECIFIED
Zeggini, EleftheriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vitart, VeroniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
St Pourcain, BeateUNSPECIFIEDorcid.org/0000-0002-4680-3517UNSPECIFIED
URN: urn:nbn:de:hbz:38-159044
DOI: 10.1038/s41467-018-07863-x
Journal or Publication Title: Nat. Commun.
Volume: 10
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; LD SCORE REGRESSION; GENETIC ARCHITECTURE; COMMON VARIANTS; GROWTH; BRAIN; GWAS; HERITABILITY; IMPUTATION; WEIGHTMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15904

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