Universität zu Köln

Prasetyanti, Pramudita R., van Hooff, Ander R., van Herwaarden, Tessa, de Vries, Nathalie, Kalloe, Kieshen, Rodermond, Hans, van Leersum, Ronald, de Jong, Joan H., Franitza, Marek, Nuernberg, Peter, Todaro, Matilde, Stassi, Giorgio and Medema, Jan Paul (2019). Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models. Int. J. Cancer, 144 (2). S. 366 - 372. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

Patient-derived xenograft (PDX) models have become an important asset in translational cancer research. However, to provide a robust preclinical platform, PDXs need to accommodate the tumor heterogeneity that is observed in patients. Colorectal cancer (CRC) can be stratified into four consensus molecular subtypes (CMS) with distinct biological and clinical features. Surprisingly, using a set of CRC patients, we revealed the partial representation of tumor heterogeneity in PDX models. The epithelial subtypes, the largest subgroups of CRC subtype, were very ineffective in establishing PDXs, indicating the need for further optimization to develop an effective personalized therapeutic approach to CRC. Moreover, we showed that tumor cell proliferation was associated with successful PDX establishment and able to distinguish patient with poor clinical outcomes within CMS2 group.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prasetyanti, Pramudita R. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Hooff, Ander R. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Herwaarden, Tessa UNSPECIFIED UNSPECIFIED UNSPECIFIED de Vries, Nathalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalloe, Kieshen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodermond, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED van Leersum, Ronald UNSPECIFIED UNSPECIFIED UNSPECIFIED de Jong, Joan H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Franitza, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Todaro, Matilde UNSPECIFIED UNSPECIFIED UNSPECIFIED Stassi, Giorgio UNSPECIFIED UNSPECIFIED UNSPECIFIED Medema, Jan Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159274
DOI:	10.1002/ijc.31767
Journal or Publication Title:	Int. J. Cancer
Volume:	144
Number:	2
Page Range:	S. 366 - 372
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBTYPES Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15927