Seidel, Danila, Meissner, Arne ORCID: 0000-0002-8506-1624, Lackner, Michaela ORCID: 0000-0001-9073-2886, Piepenbrock, Ellen, Salmanton-Garcia, Jon ORCID: 0000-0002-6766-8297, Stecher, Melanie, Mellinghoff, Sibylle ORCID: 0000-0003-3928-2503, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Graeff, Luisa Duran, Koehler, Philipp ORCID: 0000-0002-7386-7495, Cheng, Matthew P., Denis, Julie, Chedotal, Isabelle, Chander, Jagdish, Pakstis, Diana Lynn, Los-Arcos, Ibai ORCID: 0000-0001-8835-2702, Slavin, Monica, Montagna, Maria Teresa, Caggiano, Giuseppina, Mares, Mihai, Trauth, Janina, Aurbach, Ute, Vehreschild, Maria J. G. T., Vehreschild, Joerg Janne, Duarte, Rafael F., Herbrecht, Raoul, Wisplinghoff, Hilmar and Cornely, Oliver A. (2019). Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScopeA (R). Crit. Rev. Microbiol., 45 (1). S. 1 - 22. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1549-7828

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Abstract

Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised and occasionally in healthy hosts. Scedosporium spp. is intrinsically resistant to most, L. prolificans to all the antifungal drugs currently approved, raising concerns about appropriate treatment decisions. High mortality rates of up to 90% underline the need for comprehensive diagnostic workup and even more for new, effective antifungal drugs to improve patient outcome. For a comprehensive analysis, we identified cases of severe Scedosporium spp. and L. prolificans infections from the literature diagnosed in 2000 or later and the FungiScopeA (R) registry. For 208 Scedosporium spp. infections solid organ transplantation (n = 58, 27.9%) and for 56 L. prolificans infection underlying malignancy (n = 28, 50.0%) were the most prevalent risk factors. L. prolificans infections frequently presented as fungemia (n = 26, 46.4% versus n = 12, 5.8% for Scedosporium spp.). Malignancy, fungemia, CNS and lung involvement predicted worse outcome for scedosporiosis and lomentosporiosis. Patients treated with voriconazole had a better overall outcome in both groups compared to treatment with amphotericin B formulations. This review discusses the epidemiology, prognostic factors, pathogen susceptibility to approved and investigational antifungals, and treatment strategies of severe infections caused by Scedosporium spp. and L. prolificans.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meissner, ArneUNSPECIFIEDorcid.org/0000-0002-8506-1624UNSPECIFIED
Lackner, MichaelaUNSPECIFIEDorcid.org/0000-0001-9073-2886UNSPECIFIED
Piepenbrock, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmanton-Garcia, JonUNSPECIFIEDorcid.org/0000-0002-6766-8297UNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mellinghoff, SibylleUNSPECIFIEDorcid.org/0000-0003-3928-2503UNSPECIFIED
Hamprecht, AxelUNSPECIFIEDorcid.org/0000-0003-1449-5780UNSPECIFIED
Graeff, Luisa DuranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
Cheng, Matthew P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denis, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chedotal, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chander, JagdishUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pakstis, Diana LynnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Los-Arcos, IbaiUNSPECIFIEDorcid.org/0000-0001-8835-2702UNSPECIFIED
Slavin, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montagna, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caggiano, GiuseppinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mares, MihaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trauth, JaninaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aurbach, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duarte, Rafael F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herbrecht, RaoulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wisplinghoff, HilmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-159565
DOI: 10.1080/1040841X.2018.1514366
Journal or Publication Title: Crit. Rev. Microbiol.
Volume: 45
Number: 1
Page Range: S. 1 - 22
Date: 2019
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1549-7828
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CENTRAL-NERVOUS-SYSTEM; ACUTE MYELOID-LEUKEMIA; SOFT-TISSUE INFECTION; APIOSPERMUM BRAIN ABSCESSES; PSEUDALLESCHERIA-BOYDII INFECTION; FUNGAL VERTEBRAL OSTEOMYELITIS; POSTERIOR SUBTENON INJECTION; RENAL-TRANSPLANT RECIPIENT; ORBITAL APEX SYNDROME; DEEP SKIN INFECTIONMultiple languages
MicrobiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15956

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