Universität zu Köln

Yang, Xinru, Lin, Guangzhong, Han, Zhifu and Chai, Jijie (2019). Structural Biology of NOD-Like Receptors. In: Advances in Experimental Medicine and Biology, S. 119 - 142. SINGAPORE: SPRINGER-VERLAG SINGAPORE PTE LTD. ISBN 978-981-13-9367-9; 978-981-13-9366-2

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Abstract

The nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) containing (NLR) proteins are a large family of intracellular immune receptors conserved in both animals and plants. Mammalian NLRs function as pattern recognition receptors (PRRs) to sense pathogen-associated molecular patterns (PAMPs) or host-derived danger associated molecular patterns (DAMPs). PAMP or DAMP perception activates NLRs which consequently recruit pro-caspase-1 directly or indirectly. These sequential events result in formation of large multimeric protein complexes termed inflammasomes that mediate caspase-1 activation for pyroptosis and cytokine secretion. Recent structural and biochemical studies provide significant insights into the acting mechanisms of NLR proteins. In this chapter, we review and discuss these studies concerning autoinhibition, ligand recognition, activation of NLRs, and assembly of NLR inflammasomes.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Yang, Xinru UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Guangzhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Zhifu UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159889
DOI:	10.1007/978-981-13-9367-9_6
Title of Book:	Advances in Experimental Medicine and Biology
Series Name:	Adv.Exp.Med.Biol.
Volume:	1172
Page Range:	S. 119 - 142
Date:	2019
Publisher:	SPRINGER-VERLAG SINGAPORE PTE LTD
Place of Publication:	SINGAPORE
ISSN:	2214-8019
ISBN:	978-981-13-9367-9; 978-981-13-9366-2
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NLRP3 INFLAMMASOME ACTIVATION; CRYSTAL-STRUCTURE; CASPASE-1 AUTOPROTEOLYSIS; CAUSES AUTOINFLAMMATION; MECHANISTIC INSIGHTS; NUCLEOTIDE EXCHANGE; BACTERIAL LIGANDS; ATOMIC-STRUCTURE; NLRC4 CAUSES; RHO GTPASES Multiple languages Biochemistry & Molecular Biology; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15988