Gessner, Isabel ORCID: 0000-0001-9674-161X, Krakor, Eva, Styrnol, Sarah, Klimpel, Annika, Neundorf, Ines and Mathur, Sanjay (2019). Copper-free click functionalization of glucose-derived carbon spheres for tumor targeting. MRS Adv., 4 (53). S. 2881 - 2888. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 2059-8521

Full text not available from this repository.

Abstract

The dysfunctional metabolism of glucose in cancer cells represents a new avenue for cancer targeting based on sugar-derived carriers. Here, glucose-derived carbon spheres (CS) were prepared through a simple hydrothermal method, yielding highly homogenous spherical particles that exhibited excellent stability in aqueous solution. The abundant presence of surface hydroxyl functionalities was used for a subsequent condensation of an amino silane that was the basis for further covalent coupling strategies. CS were modified with a cyclooctyne derivative providing a highly selective binding site for copper-free click reactions. Moreover, the surface modification of CS with a dye-label allowed for their intracellular detection revealing a preferential uptake of CS, compared to silica particles, in tumor cells. These results thus demonstrate the highly promising potential of glucose-derived particles for tumor targeting applications and their efficient surface modification.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gessner, IsabelUNSPECIFIEDorcid.org/0000-0001-9674-161XUNSPECIFIED
Krakor, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Styrnol, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimpel, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neundorf, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathur, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-159930
DOI: 10.1557/adv.2019.488
Journal or Publication Title: MRS Adv.
Volume: 4
Number: 53
Page Range: S. 2881 - 2888
Date: 2019
Publisher: CAMBRIDGE UNIV PRESS
Place of Publication: NEW YORK
ISSN: 2059-8521
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Materials Science, MultidisciplinaryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15993

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item