Universität zu Köln

Fischer, Sarah and Eichinger, Ludwig (2019). Dictyostelium discoideum and autophagy - a perfect pair. Int. J. Dev. Biol., 63 (8-10). S. 485 - 496. BILBAO: UNIV BASQUE COUNTRY UPV-EHU PRESS. ISSN 1696-3547

Full text not available from this repository.

Abstract

Autophagy is subdivided into chaperone-mediated autophagy, microautophagy and macroautophagy and is a highly conserved intracellular degradative pathway. It is crucial for cellular homeostasis and also serves as a response to different stresses. Here we focus on macroautophagy, which targets damaged organelles and large protein assemblies, as well as pathogenic intracellular microbes for destruction. During this process, cytosolic material becomes enclosed in newly generated double-membrane vesicles, the so-called autophagosomes. Upon maturation, the autophagosome fuses with the lysosome for degradation of the cargo. The basic molecular machinery that controls macroautophagy works in a sequential order and consists of the ATG1 complex, the Ptdlns3K complex, the membrane delivery system, two ubiquitin-like conjugation systems, and autophagy adaptors and receptors. Since the different stages of macroautophagy from initiation to final degradation of cargo are tightly regulated and highly conserved across eukaryotes, simple model organisms in combination with a wide range of techniques contributed significantly to advance our understanding of this complex dynamic process. Here, we present the social amoeba Dictyostelium discoideum as an advantageous and relevant experimental model system for the analysis of macroautophagy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fischer, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichinger, Ludwig UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-160130
DOI:	10.1387/ijdb.190186LE
Journal or Publication Title:	Int. J. Dev. Biol.
Volume:	63
Number:	8-10
Page Range:	S. 485 - 496
Date:	2019
Publisher:	UNIV BASQUE COUNTRY UPV-EHU PRESS
Place of Publication:	BILBAO
ISSN:	1696-3547
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELECTIVE AUTOPHAGY; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; LC3-ASSOCIATED PHAGOCYTOSIS; ATG12-ATG5 CONJUGATE; PROTEASOME SYSTEM; SLIME-MOLD; 8 PROTEINS; DEGRADATION; MACHINERY; PATHWAY Multiple languages Developmental Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16013