Universität zu Köln

Braun, Fabian and Mueller, Roman-Ulrich (2019). Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease. In: Methods in Cell Biology, S. 43 - 54. SAN DIEGO: ELSEVIER ACADEMIC PRESS INC. ISBN 978-0-12-820336-1; 978-0-12-820335-4

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Abstract

For more than a decade, extracellular vesicles (EVs) have been the focus of extensive research efforts attempting to uncover their biological function in health and disease. Likewise, numerous studies have investigated them as a source of potential biomarkers to complement or replace the routine diagnostic procedures. Urinary extracellular vesicles take a distinct place among these studies, as they hold the promise to reflect changes in the cellular biology of the nephron and can be isolated without any invasive procedure. However, their potential has been insufficiently exploited since both their biological function and their use for diagnostic purposes in human disease have only gained increasing attention in the last years. This review aims to give an overview of the present knowledge about urinary extracellular vesicles with a special focus on novel nomenclature recommendations, current techniques for urinary EV separation and potential biomarkers that have emerged from the analysis of urinary EVs.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Braun, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-160259
DOI:	10.1016/bs.mcb.2019.04.014
Title of Book:	Methods in Cell Biology
Series Name:	Methods Cell Biol.
Volume:	154
Page Range:	S. 43 - 54
Date:	2019
Publisher:	ELSEVIER ACADEMIC PRESS INC
Place of Publication:	SAN DIEGO
ISSN:	0091-679X
ISBN:	978-0-12-820336-1; 978-0-12-820335-4
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMBRANE-VESICLES; PROTEOMIC ANALYSIS; CIRCULATING MICROPARTICLES; TRANSFERRIN RECEPTOR; EXOSOME ISOLATION; APOPTOTIC BODIES; MICROVESICLES; PROTEIN; BIOGENESIS; IDENTIFICATION Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16025