Universität zu Köln

Kalbe, Elke, Roheger, Mandy ORCID: 0000-0002-6015-3194, Paluszak, Kay, Meyer, Julia, Becker, Jutta, Fink, Gereon R., Kukolja, Juraj, Rahn, Andreas, Szabados, Florian, Wirth, Brunhilde and Kessler, Josef (2018). Effects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial. Front. Aging Neurosci., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

Full text not available from this repository.

Abstract

Background: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success. Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU. Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis. Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks. Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction. Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group x Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains. Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Roheger, Mandy UNSPECIFIED orcid.org/0000-0002-6015-3194 UNSPECIFIED Paluszak, Kay UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukolja, Juraj UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahn, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Szabados, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Brunhilde UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-161888
DOI:	10.3389/fnagi.2018.00407
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	10
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDIVIDUAL-DIFFERENCES; NEUROTROPHIC FACTOR; PARKINSONS-DISEASE; MEDITERRANEAN DIET; MENTAL ACTIVITY; AGING BRAIN; EXERCISE; BDNF; GROWTH; TERM Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16188