Universität zu Köln

Morys, Filip ORCID: 0000-0001-8996-2676, Bode, Stefan ORCID: 0000-0002-0258-7795 and Horstmann, Annette ORCID: 0000-0001-6184-8484 (2018). Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Obese individuals discount future rewards to a higher degree than lean individuals, which is generally considered disadvantageous. Moreover, their decisions are altered more easily by decision-irrelevant cues. Here, we investigated neural correlates of this phenomenon using functional MRI. We tested 30 lean and 26 obese human subjects on a primed delay discounting paradigm using gustatory and visual cues of positive, neutral and negative valence to bias their intertemporal preferences. We hypothesised that activation differences in reward-related and behavioural control areas, and changes in connectivity between these areas, would reflect the effect of these cues. Here, obese subjects were more susceptible to priming with negative gustatory cues towards delayed choices as opposed to lean subjects. This was related to lower activity in the left dorsolateral prefrontal cortex during priming. Modulation of functional connectivity between the dlPFC and the ventromedial PFC by the behavioural priming effect correlated negatively with BMI. This might indicate that default goals of obese individuals were different from those of lean participants, as the dlPFC has been suggested to be involved in internal goal pursuit. The present results further our understanding of the role of the PFC in decision-making and might inform future weight-management approaches based on non-invasive brain stimulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morys, Filip UNSPECIFIED orcid.org/0000-0001-8996-2676 UNSPECIFIED Bode, Stefan UNSPECIFIED orcid.org/0000-0002-0258-7795 UNSPECIFIED Horstmann, Annette UNSPECIFIED orcid.org/0000-0001-6184-8484 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-162454
DOI:	10.1038/s41598-018-35834-1
Journal or Publication Title:	Sci Rep
Volume:	8
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BODY-MASS INDEX; SELF-CONTROL; DELAYED MONETARY; DEFAULT MODE; QUERY-THEORY; FOOD; ROBUST; REWARD; WOMEN; ASSOCIATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16245