Carreira, Helena ORCID: 0000-0003-1538-2526, Williams, Rachael, Mueller, Martin, Harewood, Rhea, Stanway, Susannah and Bhaskaran, Krishnan (2018). Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review. JNCI-J. Natl. Cancer Inst., 110 (12). S. 1311 - 1328. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2105

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Abstract

Background: We aimed to systematically review the evidence on adverse mental health outcomes in breast cancer survivors (>= 1 year) compared with women with no history of cancer. Methods: Studies were identified by searching MEDLINE, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature, and the Social Sciences Citation Index, and through backward citation tracking. Two researchers selected the studies, extracted data, and assessed the risk of bias. Results: Sixty studies were included. Of 38 studies of depression, 33 observed more depression in breast cancer survivors; this was statistically significant in 19 studies overall, including six of seven where depression was ascertained clinically, three of four studies of antidepressants, and 13 of 31 that quantified depressive symptoms. Of 21 studies of anxiety, 17 observed more anxiety in breast cancer survivors, statistically significant in 11 studies overall, including two of four with clinical/prescription-based outcomes, and in eight of 17 of anxiety symptoms. Breast cancer survivors also had statistically significantly increased symptoms/frequency of neurocognitive dysfunction (18 of 24 studies), sexual dysfunctions (5 of 6 studies), sleep disturbance (5 of 5 studies), stress-related disorders/PTSD (2 of 3 studies), suicide (2 of 2 studies), somatisation (2 of 2 studies), and bipolar and obsessive-compulsive disorders (1 of 1 study each). Studies were heterogeneous in terms of participants' characteristics, time since diagnosis, ascertainment of outcomes, and measures reported. Approximately one-half of the studies were at high risk of selection bias and confounding by socio-economic status. Conclusions: There is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer. This information can be used to support evidence-based prevention and management strategies. Further population-based and longitudinal research would help to better characterize these associations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Carreira, HelenaUNSPECIFIEDorcid.org/0000-0003-1538-2526UNSPECIFIED
Williams, RachaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harewood, RheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanway, SusannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhaskaran, KrishnanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-162963
DOI: 10.1093/jnci/djy177
Journal or Publication Title: JNCI-J. Natl. Cancer Inst.
Volume: 110
Number: 12
Page Range: S. 1311 - 1328
Date: 2018
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1460-2105
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; LONG-TERM SURVIVORS; CARCINOMA IN-SITU; POPULATION-BASED COHORT; COGNITIVE FEATURES 10; PSYCHOLOGICAL DISTRESS; UNMET NEEDS; ADJUVANT CHEMOTHERAPY; POSTTRAUMATIC-STRESS; POSTMENOPAUSAL WOMENMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16296

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