Universität zu Köln

Dang, Ka My, Rinklin, Philipp, Afanasenkau, Dzmitry, Westmeyer, Gil, Schuerholz, Tobias, Wiegand, Simone ORCID: 0000-0001-6333-1956 and Wolfrum, Bernhard ORCID: 0000-0003-4438-3755 (2018). Chip-Based Heat Stimulation for Modulating Signal Propagation in HL-1 Cell Networks. Adv. Biosyst., 2 (12). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 2366-7478

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Abstract

Signal propagation in cardiac cell networks can be modulated by heat stimulation. Here, the response of a connected HL-1 cardiomyocyte cell network to the application of confined heat stimuli using Ca2+ imaging is investigated. Localized temperature gradients are generated by resistive heating via microwire arrays on a chip surface, which serves as a substrate for growing a confluent cell network. It is demonstrated that upon heat stimulation, the velocity of the propagating Ca2+ wave in the network is locally increased, leading to a deformation of the wavefront. Furthermore, evidence of a change in the signal propagation direction caused by a relocation of the pacemaker cell is shown. This effect might be used in future applications, where heat is employed as an alternative modality for cell stimulation protocols.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dang, Ka My UNSPECIFIED UNSPECIFIED UNSPECIFIED Rinklin, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Afanasenkau, Dzmitry UNSPECIFIED UNSPECIFIED UNSPECIFIED Westmeyer, Gil UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuerholz, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiegand, Simone UNSPECIFIED orcid.org/0000-0001-6333-1956 UNSPECIFIED Wolfrum, Bernhard UNSPECIFIED orcid.org/0000-0003-4438-3755 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163408
DOI:	10.1002/adbi.201800138
Journal or Publication Title:	Adv. Biosyst.
Volume:	2
Number:	12
Date:	2018
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	2366-7478
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Physical Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACELLULAR STIMULATION; TEMPERATURE-DEPENDENCE; MICROELECTRODE ARRAY; CALCIUM; NANOPARTICLES Multiple languages Materials Science, Biomaterials Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16340