Universität zu Köln

Wittersheim, Maike, Schallenberg, S. and Buettner, R. (2018). Non-small cell lung cancer-pathology and biology. Onkologe, 24 (12). S. 958 - 967. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

BackgroundNon-small cell lung cancer (NSCLC) accounts for ca.75% of malignant epithelial neoplasms of the lungs. In recent years profound insight has been gained regarding the molecular mechanisms of lung carcinogenesis and subsequently new targeted therapies as well as immunotherapies have been developed. These advances have had asignificant impact on routine diagnostics in pathology.ObjectiveThe article aims to give an overview of the most common histological subtypes of NSCLC as well as the morphological, immunohistochemical and molecular characteristics.Material and methodsSelective search of the PubMed database.Results and discussionAdenocarcinomas, squamous cell carcinomas and large cell carcinomas are the most common histological subtypes. With the ancillary methods available in routine pathology even poorly differentiated tumors can be assigned to these entities. The NSCLC show numerous genetic changes of which alterations of EGFR, MET, ALK1 and ROS1 are target structures for personalized therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wittersheim, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schallenberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164166
DOI:	10.1007/s00761-018-0461-5
Journal or Publication Title:	Onkologe
Volume:	24
Number:	12
Page Range:	S. 958 - 967
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL; MET; ADENOCARCINOMA; CARCINOMA; MUTATION; ROS1; GENE; IMMUNOHISTOCHEMISTRY; CLASSIFICATION; REARRANGEMENT Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16416