Universität zu Köln

Rosenkranz, Esther, Thissen, Andrea, Siegel, Sonja, Piroth, Marc, Clusmann, Hans, Gebauer, Judith, Brabant, Georg and Kreitschmann-Andermahr, Ilonka (2018). Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances. Clin. Endocrinol., 89 (6). S. 870 - 878. HOBOKEN: WILEY. ISSN 1365-2265

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Abstract

Objective Cranial irradiation for brain tumours or leukaemias has been related to cognitive, endocrine and psychosocial late effects as well as sleep disturbances and increased daytime sleepiness. Studies suggest that cranial irradiation might impact on pineal melatonin secretion. Melatonin is an important regulator in human circadian rhythms and the sleep-wake cycle. The objective of this study was to investigate melatonin secretion, subjective sleep parameters and their interplay in a cohort of cranially irradiated head and brain tumour and leukaemia survivors at least 3 years after radiotherapy. Design Cross-sectional study. Patients Thirty-eight adults. Measurements Melatonin secretion was evaluated by measuring its metabolite 6-sulphatoxymelatonin in collected overnight urine. Subjective sleep quality and daytime sleepiness were assessed using the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. The Beck Depression Inventory II was used to screen for depressive symptoms because of their impact on sleep. Results Patients irradiated in the brain midline had significantly lower melatonin secretion (P = 0.008). Subjects exhibited a high prevalence of sleeping difficulties, daytime sleepiness and depression, with females and overweight subjects particularly affected. Melatonin values and subjective sleep parameters did not correlate with each other or with treatment and most patient variables. Conclusions Our data suggest that radiation exposure to the pineal gland negatively affects melatonin secretion. This lack of pineal melatonin does not influence subjective sleep quality. As melatonin has important antioxidant and cancer-protective effects, further research is necessary to elucidate whether these patients have an increased risk of developing secondary neoplasms and other radiation late effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rosenkranz, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Thissen, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Siegel, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Piroth, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Clusmann, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebauer, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Brabant, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreitschmann-Andermahr, Ilonka UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164709
DOI:	10.1111/cen.13814
Journal or Publication Title:	Clin. Endocrinol.
Volume:	89
Number:	6
Page Range:	S. 870 - 878
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2265
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SURVIVORS; CHILDHOOD-CANCER SURVIVOR; ADULT SURVIVORS; CRANIAL IRRADIATION; DAYTIME SLEEPINESS; REACTIVE OXYGEN; QUALITY INDEX; TUMORS; CRANIOPHARYNGIOMA; CELLS Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16470