Universität zu Köln

Laut, Kamilla Gronborg, Shepherd, Leah, Gottfredsson, Magnus ORCID: 0000-0003-2465-0422, Sedlacek, Dalibor ORCID: 0000-0003-4711-6679, Knysz, Brygida, Begovac, Josip, Radoi, Roxana, Schmied, Brigitte, Chkhartishvili, Nikoloz ORCID: 0000-0002-1309-825X, Florence, Eric ORCID: 0000-0002-7004-9120, Ristola, Matti ORCID: 0000-0001-5115-2811, Faetkenheuer, Gerd, Mulcahy, Fiona, Schmid, Patrick, Kuzovatova, Elena, Paduta, Dzmitry, Smidt, Jelena, Domingo, Pere, Szlavik, Janos, Lundgren, Jens, Mocroft, Amanda and Kirk, Ole (2018). Variation in antiretroviral treatment coverage and virological suppression among three HIV key populations. Aids, 32 (18). S. 2807 - 2820. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

Objectives: We assessed differences in antiretroviral treatment (ART) coverage and virological suppression across three HIV key populations, as defined by self-reported HIV transmission category: sex between men, injection drug use (IDU) and heterosexual transmission. Design: A multinational cohort study. Methods: Within the EuroSIDA study, we assessed region-specific percentages of ART coverage among those in care and virological suppression (<500 copies/ml) among those on ART, and analysed differences between transmission categories using logistic regression. Results: Among 12 872 participants followed from 1 July 2014 to 30 June 2016, the percentages of ART-coverage and virological suppression varied between transmission categories, depending on geographical region (global P for interaction: P = 0.0148 for ART-coverage, P = 0.0006 for virological suppression). In Western [adjusted odds ratio (aOR) 1.41 (95% confidence interval 1.14-1.75)] and Northern Europe [aOR 1.68 (95% confidence interval 1.25-2.26)], heterosexuals were more likely to receive ART than MSM, while in Eastern Europe, there was some evidence that infection through IDU [aOR 0.60 (95% confidence interval 0.31-1.14)] or heterosexual contact [aOR 0.58 (95% confidence interval 0.30-1.10)] was associated with lower odds of receiving ART. In terms of virological suppression, people infected through IDU or heterosexual contact in East Central and Eastern Europe were around half as likely as MSM to have a suppressed viral load on ART, while we observed no differences in virological suppression across transmission categories in Western and Northern Europe. Conclusion: In our cohort, patterns of ART-coverage and virological suppression among key populations varied by geographical region, emphasizing the importance of tailoring HIV programmes to the local epidemic. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laut, Kamilla Gronborg UNSPECIFIED UNSPECIFIED UNSPECIFIED Shepherd, Leah UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottfredsson, Magnus UNSPECIFIED orcid.org/0000-0003-2465-0422 UNSPECIFIED Sedlacek, Dalibor UNSPECIFIED orcid.org/0000-0003-4711-6679 UNSPECIFIED Knysz, Brygida UNSPECIFIED UNSPECIFIED UNSPECIFIED Begovac, Josip UNSPECIFIED UNSPECIFIED UNSPECIFIED Radoi, Roxana UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmied, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Chkhartishvili, Nikoloz UNSPECIFIED orcid.org/0000-0002-1309-825X UNSPECIFIED Florence, Eric UNSPECIFIED orcid.org/0000-0002-7004-9120 UNSPECIFIED Ristola, Matti UNSPECIFIED orcid.org/0000-0001-5115-2811 UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulcahy, Fiona UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuzovatova, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Paduta, Dzmitry UNSPECIFIED UNSPECIFIED UNSPECIFIED Smidt, Jelena UNSPECIFIED UNSPECIFIED UNSPECIFIED Domingo, Pere UNSPECIFIED UNSPECIFIED UNSPECIFIED Szlavik, Janos UNSPECIFIED UNSPECIFIED UNSPECIFIED Lundgren, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Mocroft, Amanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirk, Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-165304
DOI:	10.1097/QAD.0000000000002035
Journal or Publication Title:	Aids
Volume:	32
Number:	18
Page Range:	S. 2807 - 2820
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-5571
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INJECTING DRUG-USERS; HEPATITIS-C VIRUS; EASTERN-EUROPE; CARE; INFECTION; CASCADE; SEX; CONTINUUM; BARRIERS; RUSSIA Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16530