Dreher, Lena-Sophie and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2018). Hepatic ERAD takes control of the organism. Embo J., 37 (22). HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

Upregulation of Endoplasmic Reticulum-Associated Degradation (ERAD) in the liver upon feeding and organismal growth aggravates proteasomal turnover of the transcription factor CREBH and decreases the expression of its target gene, the hepatokine FGF21. Wei et al and Bhattacharya et al describe the systemic coordination of energy metabolism and organismal physiology mediated by hepatic-specific ERAD function.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dreher, Lena-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoppe, ThorstenUNSPECIFIEDorcid.org/0000-0002-4734-9352UNSPECIFIED
URN: urn:nbn:de:hbz:38-165671
DOI: 10.15252/embj.2018100676
Journal or Publication Title: Embo J.
Volume: 37
Number: 22
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1460-2075
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RETICULUM-ASSOCIATED DEGRADATION; INSIGHTS; SYSTEMMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16567

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