Universität zu Köln

Delcroix, Marion, Staehler, Gerd, Gall, Henning ORCID: 0000-0001-7016-7373, Gruenig, Ekkehard, Held, Matthias, Halank, Michael, Klose, Hans, Vonk-Noordegraaf, Anton, Rosenkranz, Stephan, Pepke-Zaba, Joanna, Opitz, Christian F., Gibbs, J. Simon R., Lange, Tobias J., Tsangaris, Iraklis ORCID: 0000-0003-4395-0471, Huscher, Doerte, Pittrow, David, Olsson, Karen M. and Hoeper, Marius M. (2018). Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients. Eur. Resp. J., 52 (5). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1399-3003

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Abstract

Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension. We aimed to investigate their prognostic value in medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients from the COMPERA registry, which collects six variables of interest (World Health Organization Functional Class, 6-min walk distance, brain natriuretic peptide, right atrial pressure, cardiac index and mixed venous oxygen saturation). We included patients with at least one follow-up visit, no pulmonary endarterectomy and at least three of the six variables available, and classified the patients into low-, intermediate- and high-risk groups. As a secondary analysis, the number of noninvasive low-risk criteria was counted. The association between risk assessment and survival was evaluated. Data from inclusion and follow-up (median 7 months) visits were available for 561 and 231 patients, respectively. Baseline 1- and 5-year survival estimates were significantly different (p<0.0001) in the baseline low-risk (98.6% and 88.3%, respectively), intermediate-risk (94.9% and 61.8%, respectively) and high-risk (75.5% and 32.9%, respectively) cohorts. Follow-up data were even more discriminative, with 100%, 92% and 69% 1-year survival, respectively. The number of low-risk noninvasive criteria was also associated with survival. These analyses suggest that the ESC/ERS risk assessment may be applicable in patients with medically treated CTEPH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Delcroix, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Staehler, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Gall, Henning UNSPECIFIED orcid.org/0000-0001-7016-7373 UNSPECIFIED Gruenig, Ekkehard UNSPECIFIED UNSPECIFIED UNSPECIFIED Held, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Halank, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Klose, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Vonk-Noordegraaf, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Pepke-Zaba, Joanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Opitz, Christian F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gibbs, J. Simon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Tobias J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsangaris, Iraklis UNSPECIFIED orcid.org/0000-0003-4395-0471 UNSPECIFIED Huscher, Doerte UNSPECIFIED UNSPECIFIED UNSPECIFIED Pittrow, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Olsson, Karen M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeper, Marius M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-166875
DOI:	10.1183/13993003.00248-2018
Journal or Publication Title:	Eur. Resp. J.
Volume:	52
Number:	5
Date:	2018
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	1399-3003
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREDICTORS; RIOCIGUAT Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16687