Emons, Guenter, Steiner, Eric, Vordermark, Dirk, Uleer, Christoph, Bock, Nina, Paradies, Kerstin, Ortmann, Olaf, Aretz, Stefan ORCID: 0000-0002-5228-1890, Mallmann, Peter, Kurzeder, Christian, Hagen, Volker, van Oorschot, Birgitt, Hoecht, Stefan, Feyer, Petra, Egerer, Gerlinde, Friedrich, Michael, Cremer, Wolfgang, Prott, Franz-Josef, Horn, Lars-Christian, Prompeler, Heinrich, Langrehr, Jan, Leinung, Steffen, Beckmann, Matthias W., Kimmig, Rainer, Letsch, Anne, Reinhardt, Michael, Alt-Epping, Bernd, Kiesel, Ludwig, Menke, Jan, Gebhardt, Marion, Steinke-Lange, Verena, Rahner, Nils, Lichtenegger, Werner, Zeimet, Alain, Hanf, Volker, Weis, Joachim, Mueller, Michael, Henscher, Ulla, Schmutzler, Rita K., Meindl, Alfons, Hilpert, Felix, Panke, Joan Elisabeth, Strnad, Vratislav, Niehues, Christiane, Dauelsberg, Timm, Niehoff, Peter, Mayr, Doris, Grab, Dieter, Kreissl, Michael, Witteler, Ralf, Schorsch, Annemarie, Mustea, Alexander, Petru, Edgar, Huebner, Jutta, Rose, Anne Derke, Wight, Edward, Tholen, Reina, Bauerschmitz, Gerd J., Fleisch, Markus, Juhasz-Boess, Ingolf, Lax, Sigurd, Runnebaum, Ingo, Tempfer, Clemens ORCID: 0000-0002-6904-3258, Nothacker, Monika J., Bloedt, Susanne, Follmann, Markus ORCID: 0000-0003-3790-5578, Langer, Thomas, Raatz, Heike, Wesselmann, Simone and Erdogan, Saskia (2018). Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) - Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities. Geburtshilfe Frauenheilkd., 78 (11). S. 1089 - 1110. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8804

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Abstract

The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG). Purpose Using evidence-based, risk-adapted therapy to treat low-risk women with endometrial cancer avoids unnecessarily radical surgery and non-useful adjuvant radiotherapy and/or chemotherapy. This can significantly reduce therapy-induced morbidity and improve the patient's quality of life as well as avoiding unnecessary costs. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimal extent of surgical radicality together with the appropriate chemotherapy and/or adjuvant radiotherapy if required. An evidence-based optimal use of different therapeutic modalities should improve the survival rates and quality of life of these patients. This S3-guideline on endometrial cancer is intended as a basis for certified gynecological cancer centers. The aim is that the quality indicators established in this guideline will be incorporated in the certification processes of these centers. Methods The guideline was compiled in accordance with the requirements for S3-level guidelines. This includes, in the first instance, the adaptation of source guidelines selected using the DELBI instrument for appraising guidelines. Other consulted sources included reviews of evidence, which were compiled from literature selected during systematic searches of literature databases using the PICO scheme. In addition, an external biostatistics institute was commissioned to carry out a systematic search and assessment of the literature for one part of the guideline. Identified materials were used by the interdisciplinary working groups to develop suggestions for Recommendations and Statements, which were then subsequently modified during structured consensus conferences and/or additionally amended online using the DELPHI method, with consent between members achieved online. The guideline report is freely available online. Recommendations Part 2 of this short version of the guideline presents recommendations for the therapy of endometrial cancer including precancers and early endometrial cancer as well as recommendations on palliative medicine, psychooncology, rehabilitation, patient information and healthcare facilities to treat endometrial cancer. The management of precancers of early endometrial precancerous conditions including fertility-preserving strategies is presented. The concept used for surgical primary therapy of endometrial cancer is described. Radiotherapy and adjuvant medical therapy to treat endometrial cancer and uterine carcinosarcomas are described. Recommendations are given for the follow-up care of endometrial cancer, recurrence and metastasis. Palliative medicine, psycho-oncology including psychosocial care, and patient information and rehabilitation are presented. Finally, the care algorithm and quality assurance steps for the diagnosis, therapy and follow-up of patients with endometrial cancer are outlined.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Emons, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steiner, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vordermark, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uleer, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bock, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paradies, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ortmann, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aretz, StefanUNSPECIFIEDorcid.org/0000-0002-5228-1890UNSPECIFIED
Mallmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurzeder, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagen, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Oorschot, BirgittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoecht, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feyer, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Egerer, GerlindeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedrich, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cremer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prott, Franz-JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, Lars-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prompeler, HeinrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langrehr, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leinung, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, Matthias W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kimmig, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Letsch, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinhardt, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alt-Epping, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiesel, LudwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menke, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gebhardt, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinke-Lange, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahner, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtenegger, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeimet, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanf, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weis, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henscher, UllaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilpert, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panke, Joan ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strnad, VratislavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niehues, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dauelsberg, TimmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niehoff, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayr, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grab, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreissl, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witteler, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schorsch, AnnemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mustea, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petru, EdgarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebner, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rose, Anne DerkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wight, EdwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tholen, ReinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauerschmitz, Gerd J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleisch, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juhasz-Boess, IngolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lax, SigurdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Runnebaum, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tempfer, ClemensUNSPECIFIEDorcid.org/0000-0002-6904-3258UNSPECIFIED
Nothacker, Monika J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bloedt, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Follmann, MarkusUNSPECIFIEDorcid.org/0000-0003-3790-5578UNSPECIFIED
Langer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raatz, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wesselmann, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erdogan, SaskiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-166910
DOI: 10.1055/a-0715-2964
Journal or Publication Title: Geburtshilfe Frauenheilkd.
Volume: 78
Number: 11
Page Range: S. 1089 - 1110
Date: 2018
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1438-8804
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; PHASE-III TRIAL; STAGE-I; PELVIC RADIOTHERAPY; RADIATION-THERAPY; PHYSICAL-ACTIVITY; UTERINE CARCINOSARCOMA; CYTOREDUCTIVE SURGERY; ADJUVANT RADIOTHERAPYMultiple languages
Obstetrics & GynecologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16691

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