Universität zu Köln

Ruebsam, Matthias, Broussard, Joshua A., Wickstroem, Sara A., Nekrasova, Oxana, Green, Kathleen J. and Niessen, Carien M. (2018). Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective. Cold Spring Harbor Perspect. Biol., 10 (11). COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 1943-0264

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Abstract

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As such, these intercellular junctions are essential to provide not only integrity to epithelia and other tissues but also the mechanical machinery necessary to execute complex morphogenetic and homeostatic intercellular rearrangements. Moreover, these spatially defined junctions serve as signaling hubs that integrate mechanical and chemical pathways to coordinate tissue architecture with behavior. This review takes an evolutionary perspective on how the emergence of these two essential intercellular junctions at key points during the evolution of multicellular animals afforded metazoans with new opportunities to integrate adhesion, cytoskeletal dynamics, and signaling. We discuss known literature on cross-talk between the two junctions and, using the skin epidermis as an example, provide a model for how these two junctions function in concert to orchestrate tissue organization and function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ruebsam, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Broussard, Joshua A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nekrasova, Oxana UNSPECIFIED UNSPECIFIED UNSPECIFIED Green, Kathleen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Carien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168049
DOI:	10.1101/cshperspect.a029207
Journal or Publication Title:	Cold Spring Harbor Perspect. Biol.
Volume:	10
Number:	11
Date:	2018
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	1943-0264
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SERUM RESPONSE FACTOR; CELL-CELL ADHESION; E-CADHERIN; EPIDERMAL BARRIER; TIGHT JUNCTIONS; ALPHA-CATENIN; TERMINAL DIFFERENTIATION; EPITHELIAL POLARITY; MULTIPLE ALLERGIES; SEVERE DERMATITIS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16804