Universität zu Köln

Wickstroem, Sara A. and Niessen, Carien M. (2018). Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization. Curr. Opin. Cell Biol., 54. S. 89 - 98. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

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Abstract

Biological patterns emerge through specialization of genetically identical cells to take up distinct fates according to their position within the organism. How initial symmetry is broken to give rise to these patterns remains an intriguing open question. Several theories of patterning have been proposed, most prominently Turing's reaction-diffusion model of a slowly diffusing activator and a fast diffusing inhibitor generating periodic patterns. Although these reaction-diffusion systems can generate diverse patterns, it is becoming increasingly evident that cell shape and tension anisotropies, mediated via cell-cell and/or cell-matrix contacts, also facilitate symmetry breaking and subsequent self-organized tissue patterning. This review will highlight recent studies that implicate local changes in adhesion and/or tension as key drivers of cell rearrangements. We will also discuss recent studies on the role of cadherin and integrin adhesive receptors in mediating and responding to local tissue tension asymmetries to coordinate cell fate, position and behavior essential for tissue self-organization and maintenance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Carien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170139
DOI:	10.1016/j.ceb.2018.05.003
Journal or Publication Title:	Curr. Opin. Cell Biol.
Volume:	54
Page Range:	S. 89 - 98
Date:	2018
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0410
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALPHA-E-CATENIN; ADHERENS JUNCTIONS; STEM-CELLS; NUCLEAR MECHANOTRANSDUCTION; TOPOLOGICAL DEFECTS; FORCES; TENSION; ACTIVATION; DIVISIONS; EXTRUSION Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17013