Universität zu Köln

Kovacs, G. G., Respondek, G., van Eimeren, T., Hoeller, E., Levin, J., Mueller, U., Schwarz, S., Roesler, T. W., Schweyer, K. and Hoeglinger, G. U. (2018). Tauopathies. From molecule to therapy. Nervenarzt, 89 (10). S. 1083 - 1095. NEW YORK: SPRINGER. ISSN 1433-0407

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Abstract

Background. The microtubule-associated tau protein is the defining denominator of agroup of neurodegenerative diseases termed tauopathies. Objective. Provide atimely state of the art review on recent scientific advances in the field of tauopathies. Material and methods. Systematic review of the literature from the past 10years. Results. Tau proteins are increasingly being recognized as ahighly variable protein, underlying and defining aspectrum of molecularly defined diseases, with aclinical spectrum ranging from dementia to hypokinetic movement disorders. Genetic variation at the tau locus can trigger disease or modify disease risk. Tau protein alterations can damage nerve cells and propagate pathologies through the brain. Thus, tau proteins may serve both as aserological and imaging biomarker. Tau proteins also provide abroad spectrum of rational therapeutic interventions to prevent disease progression. This knowledge has led to modern clinical trials. Conclusion. The field of tauopathies is in a state of dynamic and rapid progress, requiring close interdisciplinary collaboration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kovacs, G. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Respondek, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeller, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Levin, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roesler, T. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schweyer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeglinger, G. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170427
DOI:	10.1007/s00115-018-0584-3
Journal or Publication Title:	Nervenarzt
Volume:	89
Number:	10
Page Range:	S. 1083 - 1095
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0407
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE SUPRANUCLEAR PALSY; CORTICOBASAL DEGENERATION; ALZHEIMERS-DISEASE; DOUBLE-BLIND; TAU; NEUROPATHOLOGY; TIDEGLUSIB; BIOMARKERS; CRITERIA; TRIAL Multiple languages Clinical Neurology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17042