Universität zu Köln

Herrmann, Anke, Sandmann, Lisa, Adams, Ortwin, Herrmann, Dominik, Dirks, Miriam, Widera, Marek, Westhaus, Sandra, Kaiser, Rolf, di Cristanziano, Veronica, Manns, Michael P., Korth, Johannes, Richter, Nico, Anastasiou, Olympia, Timm, Joerg, von Hahn, Thomas and Ciesek, Sandra ORCID: 0000-0002-1802-7565 (2018). Role of BK polyomavirus (BKV) and Torque teno virus (TTV) in liver transplant recipients with renal impairment. J. Med. Microbiol., 67 (10). S. 1496 - 1509. LONDON: MICROBIOLOGY SOC. ISSN 1473-5644

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Abstract

Purpose. Renal impairment is a common complication after liver transplantation (LT). While BK polyomavirus (BKV) has been linked to renal failure in kidney transplant recipients, Torque teno virus (TTV) is a surrogate marker for immunosuppression that does not have a clear association with any human disease. The impact of BKV and TTV on renal impairment after LT is unknown. Methodology. In this retrospective study, urine and serum samples from 136 liver transplant recipients were screened for BKV and TTV by quantitative PCR. In addition, serum was screened for BKV-specific antibodies and the VP1 typing region was sequenced for BKV genotyping. All parameters were correlated with clinical data. Results/Key findings. BK viruria was detected up to 21 years after transplantation in 16.9% of cases. BK viraemia was detected in 8.7% of patients with BK viruria up to 4 years after LT. BKV-specific antibodies were detected in 93.6% of all LT recipients and correlated with BKV viral load in urine. There was no correlation between renal impairment and the detection of BK DNA in urine (OR 0.983). TTV DNA was detected in 84.6% of serum samples and in 66.6% of urine samples. The TTV viral load in serum correlated with the BKV viral load but had no impact on renal impairment. Conclusion. Our data indicate that the detection of BKV and TTV is not a risk factor for renal impairment after LT. A correlation of TTV and BKV viral load seems to be an indicator for the immune status of the host.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herrmann, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandmann, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Adams, Ortwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrmann, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Dirks, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Widera, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Westhaus, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Manns, Michael P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Korth, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED Anastasiou, Olympia UNSPECIFIED UNSPECIFIED UNSPECIFIED Timm, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED von Hahn, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciesek, Sandra UNSPECIFIED orcid.org/0000-0002-1802-7565 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170959
DOI:	10.1099/jmm.0.000823
Journal or Publication Title:	J. Med. Microbiol.
Volume:	67
Number:	10
Page Range:	S. 1496 - 1509
Date:	2018
Publisher:	MICROBIOLOGY SOC
Place of Publication:	LONDON
ISSN:	1473-5644
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOLID-ORGAN TRANSPLANTATION; KIDNEY-TRANSPLANTATION; CLINICAL-ASPECTS; BLOOD-DONORS; INFECTION; VIREMIA; ANTIBODY; DISEASE; REPLICATION; PREVALENCE Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17095