Universität zu Köln

Hochreiter, Marcel, Uhling, Maria, Sisic, Leila, Bruckner, Thomas, Heininger, Alexandra, Hohn, Andreas, Ott, Katja, Schmidt, Thomas ORCID: 0000-0002-7166-3675, Berger, Marc Moritz, Richter, Daniel Christoph, Buechler, Markus, Weigand, Markus Alexander and Busch, Cornelius Johannes (2018). Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30days: a retrospective before-and-after analysis. Infection, 46 (5). S. 617 - 625. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

PurposeThoracoabdominal esophageal resection for malignant disease is frequently associated with pulmonary infection. Whether prolonged antibiotic prophylaxis beyond a single perioperative dose is advantageous in preventing pulmonary infection after thoracoabdominal esophagectomy remains unclear.MethodsIn this retrospective before-and-after analysis, 173 patients between January 2009 and December 2014 from a prospectively maintained database were included. We evaluated the effect of a 5-day postoperative course of moxifloxacin, which is a frequently used antimicrobial agent for pneumonia, on the incidence of pulmonary infection and mortality after thoracoabdominal esophagectomy.Results104 patients received only perioperative antimicrobial prophylaxis (control group) and 69 additionally received a 5-day postoperative antibiotic therapy with moxifloxacin (prolonged-course). 22 (12.7%) of all patients developed pneumonia within the first 30days after surgery. No statistically significant differences were seen between the prolonged group and control group in terms of pneumonia after 7 (p=0.169) or 30days (p=0.133), detected bacterial species (all p>0.291) and 30-day mortality (5.8 vs 10.6%, p=0.274).ConclusionA preemptive 5-day postoperative course of moxifloxacin does not reduce the incidence of pulmonary infection and does not improve mortality after thoracoabdominal esophagectomy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hochreiter, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhling, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Sisic, Leila UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruckner, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heininger, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohn, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thomas UNSPECIFIED orcid.org/0000-0002-7166-3675 UNSPECIFIED Berger, Marc Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Daniel Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Buechler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Weigand, Markus Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Busch, Cornelius Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-171018
DOI:	10.1007/s15010-018-1160-2
Journal or Publication Title:	Infection
Volume:	46
Number:	5
Page Range:	S. 617 - 625
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTOPERATIVE PULMONARY COMPLICATIONS; VENTILATOR-ASSOCIATED PNEUMONIA; CRITICALLY-ILL PATIENTS; TRANSTHORACIC ESOPHAGECTOMY; AIRWAY COLONIZATION; ACQUIRED PNEUMONIA; ELDERLY-PATIENTS; CANCER; SURGERY; MANAGEMENT Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17101