Universität zu Köln

Cornely, Oliver A. and Kontoyiannis, Dimitrios P. (2018). How to prophylax against invasive fungal infections in adult ALL? An unmet need. Mycoses, 61 (9). S. 646 - 650. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Although the benefit for any type of antifungal prophylaxis in patients with acute myelogenous leukaemia is well accepted, less is known about the risk for invasive fungal infections (IFIs) and the optimal prophylaxis strategies in patients with acute lymphocytic leukaemia (ALL). Based on recent studies, ALL is a disease that appears to be associated with significant risk for IFIs. The pharmacokinetic interactions between azoles and vincristine, an antineoplastic agent that is part of modern combination chemotherapies in ALL, results in clinically significant neurotoxicity that makes the use of azoles problematic. However, a number of questions regarding azole-vincristine interactions remain unanswered. In this viewpoint, we call for a renewed interest in antifungal prophylaxis studies in ALL in view of the availability of several non-azole novel antifungal agents that are under preclinical and/or clinical development. This is clearly a major unmet need in modern clinical mycology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kontoyiannis, Dimitrios P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-175691
DOI:	10.1111/myc.12786
Journal or Publication Title:	Mycoses
Volume:	61
Number:	9
Page Range:	S. 646 - 650
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE LYMPHOBLASTIC-LEUKEMIA; PRIMARY ANTIFUNGAL PROPHYLAXIS; PERIPHERAL NEUROPATHY; VINCRISTINE; THERAPY; ITRACONAZOLE; CASPOFUNGIN; CHILDREN; DISEASES; AGENTS Multiple languages Dermatology; Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17569