Universität zu Köln

Halbach, Marcel, Abraham, William T., Butter, Christian, Ducharme, Anique ORCID: 0000-0003-1681-9187, Klug, Didier, Little, William C., Reuter, Hannes, Schafer, Jill E., Senni, Michele, Swarup, Vijay, Wachter, Rolf ORCID: 0000-0003-2231-2200, Weaver, Fred A., Wilks, Seth J., Zile, Michael R. and Mueller-Ehmsen, Jochen (2018). Baroreflex activation therapy for the treatment of heart failure with reduced ejection fraction in patients with and without coronary artery disease. Int. J. Cardiol., 266. S. 187 - 193. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Background: In a randomized trial, baroreflex activation therapy (BAT) improved exercise capacity, quality of life and NT-proBNP in patients with heart failure with reduced ejection fraction (HFrEF). In view of different mechanisms underlying HFrEF, we performed a post-hoc subgroup analysis of efficacy and safety of BAT in patients with and without coronary artery disease (CAD). Methods and results: Patients with left ventricular ejection fraction <35% and NYHA Class III were randomized 1:1 to guideline-directedmedical and device therapy alone or plus BAT. Patients with a history of CAD, priormyocardial infarction or coronary artery bypass graft were assigned to the CAD group with all others assigned to the no-CAD group. Of 71 BAT treated patients, 52 had CAD and 19 had no CAD. In the control group, 49 of 69 patients had CAD and 20 had no CAD. The system-or procedure-related major adverse neurological or cardiovascular event rate was 3.8% in the CAD group vs. 0% in the no-CAD group (p = 1.0). In the whole cohort, NYHA Class, Minnesota Living with Heart Failure score, 6-minute hall walk distance and NTproBNP were improved in BAT treated patients compared with controls. Statistical analyses revealed no interaction between the presence of CAD and effect of BAT (all p > 0.05). Conclusion: No major differences were found in BAT efficacy or safety between patients with and without CAD, indicating that BAT improves exercise capacity, quality of life and NTproBNP in patients with ischemic and non-ischemic cardiomyopathy. (C) 2018 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Halbach, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Abraham, William T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Butter, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ducharme, Anique UNSPECIFIED orcid.org/0000-0003-1681-9187 UNSPECIFIED Klug, Didier UNSPECIFIED UNSPECIFIED UNSPECIFIED Little, William C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Schafer, Jill E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Senni, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Swarup, Vijay UNSPECIFIED UNSPECIFIED UNSPECIFIED Wachter, Rolf UNSPECIFIED orcid.org/0000-0003-2231-2200 UNSPECIFIED Weaver, Fred A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilks, Seth J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zile, Michael R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Ehmsen, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-175897
DOI:	10.1016/j.ijcard.2018.04.075
Journal or Publication Title:	Int. J. Cardiol.
Volume:	266
Page Range:	S. 187 - 193
Date:	2018
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1874-1754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC RESYNCHRONIZATION; ISCHEMIC CARDIOMYOPATHY; BLOOD-PRESSURE; SAFETY; ETIOLOGY; EFFICACY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17589