Universität zu Köln

Wagner, Jonathan, Agostoni, Piergiuseppe ORCID: 0000-0002-8345-6382, Arena, Ross ORCID: 0000-0002-6675-1996, Belardinelli, Romualdo, Dumitrescu, Daniel, Hager, Alfred ORCID: 0000-0002-2481-2017, Myers, Jonathan, Rauramaa, Rainer, Riley, Marshall, Takken, Tim and Schmidt-Trucksass, Arno ORCID: 0000-0002-4662-3911 (2018). The Role of Gas Exchange Variables in Cardiopulmonary Exercise Testing for Risk Stratification and Management of Heart Failure with Reduced Ejection Fraction. Am. Heart J., 202. S. 116 - 127. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-5330

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Abstract

Heart failure with reduced ejection fraction (HFrEF) is common in the developed world and results in significant morbidity and mortality. Accurate risk assessment methods and prognostic variables are therefore needed to guide clinical decision making for medical therapy and surgical interventions with the ultimate goal of decreasing risk and improving health outcomes. The purpose of this review is to examine the role of cardiopulmonary exercise testing (CPET) and its most commonly used ventilatory gas exchange variables for the purpose of risk stratification and management of HFrEF. We evaluated five widely studied gas exchange variables from CPET in HFrEF patients based on nine previously used systematic criteria for biomarkers. This paper provides clinicians with a comprehensive and critical overview, class recommendations and evidence levels. Although some CPET variables met more criteria than others, evidence supporting the clinical assessment of variables beyond peak VO2 is well-established. A multi-variable approach also including the V-E-VCO2 slope and EOV is therefore recommended. (C) 2018 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagner, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Agostoni, Piergiuseppe UNSPECIFIED orcid.org/0000-0002-8345-6382 UNSPECIFIED Arena, Ross UNSPECIFIED orcid.org/0000-0002-6675-1996 UNSPECIFIED Belardinelli, Romualdo UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumitrescu, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hager, Alfred UNSPECIFIED orcid.org/0000-0002-2481-2017 UNSPECIFIED Myers, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauramaa, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Riley, Marshall UNSPECIFIED UNSPECIFIED UNSPECIFIED Takken, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt-Trucksass, Arno UNSPECIFIED orcid.org/0000-0002-4662-3911 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177055
DOI:	10.1016/j.ahj.2018.05.009
Journal or Publication Title:	Am. Heart J.
Volume:	202
Page Range:	S. 116 - 127
Date:	2018
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-5330
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UPTAKE EFFICIENCY SLOPE; PEAK OXYGEN-CONSUMPTION; TIDAL CARBON-DIOXIDE; CARDIORESPIRATORY FUNCTIONAL RESERVE; EXERTIONAL OSCILLATORY VENTILATION; CARDIAC RESYNCHRONIZATION THERAPY; MEMBRANE DIFFUSING-CAPACITY; BETA-BLOCKER THERAPY; QUALITY-OF-LIFE; PROGNOSTIC-SIGNIFICANCE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17705