Universität zu Köln

Viehmann, Susanne F., Boehner, Alexander M. C., Kurts, Christian and Braehler, Sebastian (2018). The multifaceted role of the renal mononuclear phagocyte system. Cell. Immunol., 330. S. 97 - 105. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2163

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Abstract

The kidney contains a large and complex network of mononuclear phagocytes, which includes dendritic cells (DCs) and macrophages (MOs). The distinction between these cell types is traditionally based on the expression of molecular markers and morphology. However, several classification systems are used in parallel to identify DCs and MOs, leading to considerable uncertainty about their identity and functional roles. The discovery that a substantial proportion of macrophages in tissues like the kidney are embryonically derived further complicates the situation. Recent studies have used newly identified transcription factors such as ZBTB46 and lineage tracing techniques for classifying mononuclear phagocytes. These approaches have shed new light on the functional specialization of these cells in health and disease, uncovered an influence of the renal microenvironment and revealed considerable cellular plasticity, especially in inflammatory situations. In this review, the current knowledge about the developmental origins and versatile functional roles of DCs and MOs in kidney homeostasis and disease is discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Viehmann, Susanne F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehner, Alexander M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurts, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Braehler, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-178216
DOI:	10.1016/j.cellimm.2018.04.009
Journal or Publication Title:	Cell. Immunol.
Volume:	330
Page Range:	S. 97 - 105
Date:	2018
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2163
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ISCHEMIA-REPERFUSION INJURY; PLASMACYTOID DENDRITIC CELLS; HEMATOPOIETIC STEM-CELLS; MURINE OBSTRUCTIVE NEPHROPATHY; TISSUE-RESIDENT MACROPHAGES; PERIPHERAL LYMPHOID ORGANS; ACUTE KIDNEY INJURY; REGULATORY T-CELLS; IN-VIVO; CRESCENTIC GLOMERULONEPHRITIS Multiple languages Cell Biology; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17821