Universität zu Köln

Langhammer, Kristina ORCID: 0000-0002-8104-0308, Roth, Bernhard, Kribs, Angela ORCID: 0000-0002-0477-5474, Goepel, Wolfgang, Kuntz, Ludwig ORCID: 0000-0002-4083-4574 and Miedaner, Felix ORCID: 0000-0003-2337-9722 (2018). Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study. Eur. J. Pediatr., 177 (8). S. 1207 - 1218. NEW YORK: SPRINGER. ISSN 1432-1076

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Abstract

The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants and add new aspects concerning treatment and outcome data collected in the routine clinical setting. Four hundred seven very low birth weight infants who received surfactant via either LISA or intubation methods were enrolled in the observational cross-sectional multicenter study. To compare infants in terms of surfactant administration, we used an exact matching procedure (the same gestational age, severe perinatal depression (pH < 7.10), birth weight < 10th percentile, antenatal steroid treatment, and the same gender). To check for robustness, we performed repeated matching. LISA-treated infants required significantly less mechanical ventilation during hospital stay (p < 0.001) and days with supplemental oxygen (p = 0.03). Analgesics and sedatives were used less often during the stay (p < 0.001). Infants treated with LISA had significantly lower rates of bronchopulmonary dysplasia (p = 0.003). LISA failure infants were identified as more likely to be small for gestational age and more immature. Conclusion: Our study complements former results with advantages for LISA-treated infants in mechanical ventilation and bronchopulmonary dysplasia in the clinical routine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langhammer, Kristina UNSPECIFIED orcid.org/0000-0002-8104-0308 UNSPECIFIED Roth, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED orcid.org/0000-0002-0477-5474 UNSPECIFIED Goepel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuntz, Ludwig UNSPECIFIED orcid.org/0000-0002-4083-4574 UNSPECIFIED Miedaner, Felix UNSPECIFIED orcid.org/0000-0003-2337-9722 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179178
DOI:	10.1007/s00431-018-3179-x
Journal or Publication Title:	Eur. J. Pediatr.
Volume:	177
Number:	8
Page Range:	S. 1207 - 1218
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1076
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language BREATHING PRETERM INFANTS; RESPIRATORY-DISTRESS; NEURODEVELOPMENTAL OUTCOMES; CONTROLLED-TRIAL; VLBW INFANTS; MORTALITY; METAANALYSIS; MORPHINE; THERAPY; ASSOCIATION Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17917